Emergence and Enhancement of Ultrasensitivity through Posttranslational Modulation of Protein Stability

Signal amplification in biomolecular networks converts a linear input to a steeply sigmoid output and is central to a number of cellular functions including proliferation, differentiation, homeostasis, adaptation, and biological rhythms. One canonical signal amplifying motif is zero-order ultrasensi...

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Bibliographic Details
Main Authors: Carla M. Kumbale, Eberhard O. Voit, Qiang Zhang
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/165739fa56c54e978843c34bbcc2c026
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