Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putatively different functions.

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Autores principales:	Michael Bartoschek, Nikolay Oskolkov, Matteo Bocci, John Lövrot, Christer Larsson, Mikael Sommarin, Chris D. Madsen, David Lindgren, Gyula Pekar, Göran Karlsson, Markus Ringnér, Jonas Bergh, Åsa Björklund, Kristian Pietras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
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spelling	oai:doaj.org-article:1659aa31381d4c7a92e2ff7e1c638daf2021-12-02T17:33:16ZSpatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing10.1038/s41467-018-07582-32041-1723https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07582-3https://doaj.org/toc/2041-1723Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putatively different functions.Michael BartoschekNikolay OskolkovMatteo BocciJohn LövrotChrister LarssonMikael SommarinChris D. MadsenDavid LindgrenGyula PekarGöran KarlssonMarkus RingnérJonas BerghÅsa BjörklundKristian PietrasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Bartoschek Nikolay Oskolkov Matteo Bocci John Lövrot Christer Larsson Mikael Sommarin Chris D. Madsen David Lindgren Gyula Pekar Göran Karlsson Markus Ringnér Jonas Bergh Åsa Björklund Kristian Pietras Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
description	Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putatively different functions.
format	article
author	Michael Bartoschek Nikolay Oskolkov Matteo Bocci John Lövrot Christer Larsson Mikael Sommarin Chris D. Madsen David Lindgren Gyula Pekar Göran Karlsson Markus Ringnér Jonas Bergh Åsa Björklund Kristian Pietras
author_facet	Michael Bartoschek Nikolay Oskolkov Matteo Bocci John Lövrot Christer Larsson Mikael Sommarin Chris D. Madsen David Lindgren Gyula Pekar Göran Karlsson Markus Ringnér Jonas Bergh Åsa Björklund Kristian Pietras
author_sort	Michael Bartoschek
title	Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
title_short	Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
title_full	Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
title_fullStr	Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
title_full_unstemmed	Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
title_sort	spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell rna sequencing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
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Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

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