Acceleration-induced pressure gradients and cavitation in soft biomaterials

Abstract The transient, dynamic response of soft materials to mechanical impact has become increasingly relevant due to the emergence of numerous biomedical applications, e.g., accurate assessment of blunt injuries to the human body. Despite these important implications, acceleration-induced pressur...

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Autores principales:	Wonmo Kang, Marc Raphael
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Critical Acceleration Bubble Burst Soft Material Samples Agarose Samples Cavitation Nucleation Medicine R Science Q
Acceso en línea:	https://doaj.org/article/165c0d7603f34616940710c6239e551f
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spelling	oai:doaj.org-article:165c0d7603f34616940710c6239e551f2021-12-02T15:08:25ZAcceleration-induced pressure gradients and cavitation in soft biomaterials10.1038/s41598-018-34085-42045-2322https://doaj.org/article/165c0d7603f34616940710c6239e551f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34085-4https://doaj.org/toc/2045-2322Abstract The transient, dynamic response of soft materials to mechanical impact has become increasingly relevant due to the emergence of numerous biomedical applications, e.g., accurate assessment of blunt injuries to the human body. Despite these important implications, acceleration-induced pressure gradients in soft materials during impact and the corresponding material response, from small deformations to sudden bubble bursts, are not fully understood. Both through experiments and theoretical analyses, we empirically show, using collagen and agarose model systems, that the local pressure in a soft sample is proportional to the square of the sample depth in the impact direction. The critical acceleration that corresponds to bubble bursts increases with increasing gel stiffness. Bubble bursts are also highly sensitive to the initial bubble size, e.g., bubble bursts can occur only when the initial bubble diameter is smaller than a critical size (≈10 μm). Our study gives fundamental insight into the physics of injury mechanisms, from blunt trauma to cavitation-induced brain injury.Wonmo KangMarc RaphaelNature PortfolioarticleCritical AccelerationBubble BurstSoft Material SamplesAgarose SamplesCavitation NucleationMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Critical Acceleration Bubble Burst Soft Material Samples Agarose Samples Cavitation Nucleation Medicine R Science Q
spellingShingle	Critical Acceleration Bubble Burst Soft Material Samples Agarose Samples Cavitation Nucleation Medicine R Science Q Wonmo Kang Marc Raphael Acceleration-induced pressure gradients and cavitation in soft biomaterials
description	Abstract The transient, dynamic response of soft materials to mechanical impact has become increasingly relevant due to the emergence of numerous biomedical applications, e.g., accurate assessment of blunt injuries to the human body. Despite these important implications, acceleration-induced pressure gradients in soft materials during impact and the corresponding material response, from small deformations to sudden bubble bursts, are not fully understood. Both through experiments and theoretical analyses, we empirically show, using collagen and agarose model systems, that the local pressure in a soft sample is proportional to the square of the sample depth in the impact direction. The critical acceleration that corresponds to bubble bursts increases with increasing gel stiffness. Bubble bursts are also highly sensitive to the initial bubble size, e.g., bubble bursts can occur only when the initial bubble diameter is smaller than a critical size (≈10 μm). Our study gives fundamental insight into the physics of injury mechanisms, from blunt trauma to cavitation-induced brain injury.
format	article
author	Wonmo Kang Marc Raphael
author_facet	Wonmo Kang Marc Raphael
author_sort	Wonmo Kang
title	Acceleration-induced pressure gradients and cavitation in soft biomaterials
title_short	Acceleration-induced pressure gradients and cavitation in soft biomaterials
title_full	Acceleration-induced pressure gradients and cavitation in soft biomaterials
title_fullStr	Acceleration-induced pressure gradients and cavitation in soft biomaterials
title_full_unstemmed	Acceleration-induced pressure gradients and cavitation in soft biomaterials
title_sort	acceleration-induced pressure gradients and cavitation in soft biomaterials
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/165c0d7603f34616940710c6239e551f
work_keys_str_mv	AT wonmokang accelerationinducedpressuregradientsandcavitationinsoftbiomaterials AT marcraphael accelerationinducedpressuregradientsandcavitationinsoftbiomaterials
_version_	1718388106582818816

Acceleration-induced pressure gradients and cavitation in soft biomaterials

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