The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independent of Thr172 phosphorylation in the kinase activation...

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Autores principales:	Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp, Jonathan S. Oakhill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a6
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spelling	oai:doaj.org-article:165d7eeb69bd4fda9ad259d85d17b5a62021-12-02T15:37:04ZThe autophagy initiator ULK1 sensitizes AMPK to allosteric drugs10.1038/s41467-017-00628-y2041-1723https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a62017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00628-yhttps://doaj.org/toc/2041-1723AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independent of Thr172 phosphorylation in the kinase activation loop.Toby A. DiteNaomi X. Y. LingJohn W. ScottAshfaqul HoqueSandra GalicBenjamin L. ParkerKevin R. W. NgoeiChristopher G. LangendorfMatthew T. O’BrienMondira KunduBenoit ViolletGregory R. SteinbergKei SakamotoBruce E. KempJonathan S. OakhillNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Toby A. Dite Naomi X. Y. Ling John W. Scott Ashfaqul Hoque Sandra Galic Benjamin L. Parker Kevin R. W. Ngoei Christopher G. Langendorf Matthew T. O’Brien Mondira Kundu Benoit Viollet Gregory R. Steinberg Kei Sakamoto Bruce E. Kemp Jonathan S. Oakhill The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
description	AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independent of Thr172 phosphorylation in the kinase activation loop.
format	article
author	Toby A. Dite Naomi X. Y. Ling John W. Scott Ashfaqul Hoque Sandra Galic Benjamin L. Parker Kevin R. W. Ngoei Christopher G. Langendorf Matthew T. O’Brien Mondira Kundu Benoit Viollet Gregory R. Steinberg Kei Sakamoto Bruce E. Kemp Jonathan S. Oakhill
author_facet	Toby A. Dite Naomi X. Y. Ling John W. Scott Ashfaqul Hoque Sandra Galic Benjamin L. Parker Kevin R. W. Ngoei Christopher G. Langendorf Matthew T. O’Brien Mondira Kundu Benoit Viollet Gregory R. Steinberg Kei Sakamoto Bruce E. Kemp Jonathan S. Oakhill
author_sort	Toby A. Dite
title	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
title_short	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
title_full	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
title_fullStr	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
title_full_unstemmed	The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
title_sort	autophagy initiator ulk1 sensitizes ampk to allosteric drugs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a6
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The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

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