The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

AMPK is involved in sensing of metabolic stress. The authors show that the autophagy initiator ULK1 phosphorylates β1-Ser108 on the regulatory β1-subunit, sensitizing AMPK to allosteric drugs, and activates signaling pathways that appear independent of Thr172 phosphorylation in the kinase activation...

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Auteurs principaux: Toby A. Dite, Naomi X. Y. Ling, John W. Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L. Parker, Kevin R. W. Ngoei, Christopher G. Langendorf, Matthew T. O’Brien, Mondira Kundu, Benoit Viollet, Gregory R. Steinberg, Kei Sakamoto, Bruce E. Kemp, Jonathan S. Oakhill
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
Q
Accès en ligne:https://doaj.org/article/165d7eeb69bd4fda9ad259d85d17b5a6
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