Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

Abstract Hyperphosphataemia is treated with phosphate binders, which can cause adverse effects. Spray-dried synbiotic powder (SP) composed of Lactobacillus casei JCM1134 (a phosphate-accumulating organism; PAO) and Aloe vera is potentially a safer alternative for efficient phosphate removal. In this...

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Autores principales:	Ajeeta Anand, Shigeki Yoshida, Hideki Aoyagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1666134e1731471e83a52cc9e966f979
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spelling	oai:doaj.org-article:1666134e1731471e83a52cc9e966f9792021-12-02T18:51:01ZTailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)10.1038/s41598-021-95176-32045-2322https://doaj.org/article/1666134e1731471e83a52cc9e966f9792021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95176-3https://doaj.org/toc/2045-2322Abstract Hyperphosphataemia is treated with phosphate binders, which can cause adverse effects. Spray-dried synbiotic powder (SP) composed of Lactobacillus casei JCM1134 (a phosphate-accumulating organism; PAO) and Aloe vera is potentially a safer alternative for efficient phosphate removal. In this study, a novel strategy was developed; lysine-derivatized deacetylated A. vera (DAVK) was synthesised and fabricated on phosphate-deficient PAO (PDP) for efficient phosphate transfer and then spray-dried with the supernatant of DAV centrifugation to form a sacrificial layer on PDP for SP integrity during gastric passage. In vitro experiments revealed that PAO removed only 1.6% of the phosphate from synthetic media, whereas SP removed 89%, 87%, and 67% (w/v) of the phosphate from milk, soft drink, and synthetic media, respectively, confirming the protective role of A. vera and efficient phosphate transport. Compared with commercial binders, SP effectively removed phosphate from synthetic media, whereas SP and CaCO3 exhibited comparative results for milk and soft drink. Importantly, CaCO3 caused hypercalcaemia. Thus, the described SP presents a promising tool to prevent hyperphosphataemia. This study also revealed a novel factor: diets of patients with chronic kidney disease should be monitored to determine the optimal phosphate binders, as phosphate removal performance depends on the accessible phosphate forms.Ajeeta AnandShigeki YoshidaHideki AoyagiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ajeeta Anand Shigeki Yoshida Hideki Aoyagi Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
description	Abstract Hyperphosphataemia is treated with phosphate binders, which can cause adverse effects. Spray-dried synbiotic powder (SP) composed of Lactobacillus casei JCM1134 (a phosphate-accumulating organism; PAO) and Aloe vera is potentially a safer alternative for efficient phosphate removal. In this study, a novel strategy was developed; lysine-derivatized deacetylated A. vera (DAVK) was synthesised and fabricated on phosphate-deficient PAO (PDP) for efficient phosphate transfer and then spray-dried with the supernatant of DAV centrifugation to form a sacrificial layer on PDP for SP integrity during gastric passage. In vitro experiments revealed that PAO removed only 1.6% of the phosphate from synthetic media, whereas SP removed 89%, 87%, and 67% (w/v) of the phosphate from milk, soft drink, and synthetic media, respectively, confirming the protective role of A. vera and efficient phosphate transport. Compared with commercial binders, SP effectively removed phosphate from synthetic media, whereas SP and CaCO3 exhibited comparative results for milk and soft drink. Importantly, CaCO3 caused hypercalcaemia. Thus, the described SP presents a promising tool to prevent hyperphosphataemia. This study also revealed a novel factor: diets of patients with chronic kidney disease should be monitored to determine the optimal phosphate binders, as phosphate removal performance depends on the accessible phosphate forms.
format	article
author	Ajeeta Anand Shigeki Yoshida Hideki Aoyagi
author_facet	Ajeeta Anand Shigeki Yoshida Hideki Aoyagi
author_sort	Ajeeta Anand
title	Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
title_short	Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
title_full	Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
title_fullStr	Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
title_full_unstemmed	Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
title_sort	tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1666134e1731471e83a52cc9e966f979
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Tailored synbiotic powder (functional food) to prevent hyperphosphataemia (kidney disorder)

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