Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis

Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-6 pathway abolishes FGF19-induced HCC without side...

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Autores principales:	Mei Zhou, Hong Yang, R. Marc Learned, Hui Tian, Lei Ling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1666989d05a642a7880186e1fdbad158
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spelling	oai:doaj.org-article:1666989d05a642a7880186e1fdbad1582021-12-02T14:42:07ZNon-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis10.1038/ncomms154332041-1723https://doaj.org/article/1666989d05a642a7880186e1fdbad1582017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15433https://doaj.org/toc/2041-1723Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-6 pathway abolishes FGF19-induced HCC without side effects.Mei ZhouHong YangR. Marc LearnedHui TianLei LingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mei Zhou Hong Yang R. Marc Learned Hui Tian Lei Ling Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
description	Fibroblast Growth Factor 19 (FGF19) neutralizing antibodies inhibit hepatocellular carcinoma (HCC) growth but have safety issues. Here, the authors show that FGF19 promotes HCC by activating STAT3 signalling via IL-6 production and that targeting IL-6 pathway abolishes FGF19-induced HCC without side effects.
format	article
author	Mei Zhou Hong Yang R. Marc Learned Hui Tian Lei Ling
author_facet	Mei Zhou Hong Yang R. Marc Learned Hui Tian Lei Ling
author_sort	Mei Zhou
title	Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
title_short	Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
title_full	Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
title_fullStr	Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
title_full_unstemmed	Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
title_sort	non-cell-autonomous activation of il-6/stat3 signaling mediates fgf19-driven hepatocarcinogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1666989d05a642a7880186e1fdbad158
work_keys_str_mv	AT meizhou noncellautonomousactivationofil6stat3signalingmediatesfgf19drivenhepatocarcinogenesis AT hongyang noncellautonomousactivationofil6stat3signalingmediatesfgf19drivenhepatocarcinogenesis AT rmarclearned noncellautonomousactivationofil6stat3signalingmediatesfgf19drivenhepatocarcinogenesis AT huitian noncellautonomousactivationofil6stat3signalingmediatesfgf19drivenhepatocarcinogenesis AT leiling noncellautonomousactivationofil6stat3signalingmediatesfgf19drivenhepatocarcinogenesis
_version_	1718389794603532288

Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis

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