Fibroblast Memory in Development, Homeostasis and Disease

Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cel...

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Autores principales:	Thomas Kirk, Abubkr Ahmed, Emanuel Rognoni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biological memory fibroblasts wound healing fibrosis cancer inflammation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1669ef7116944a60947388ffd037489a
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id	oai:doaj.org-article:1669ef7116944a60947388ffd037489a
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spelling	oai:doaj.org-article:1669ef7116944a60947388ffd037489a2021-11-25T17:07:49ZFibroblast Memory in Development, Homeostasis and Disease10.3390/cells101128402073-4409https://doaj.org/article/1669ef7116944a60947388ffd037489a2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2840https://doaj.org/toc/2073-4409Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cell population that constantly responds and adapts to their environment. Biological memory is the process of a sustained altered cellular state and functions in response to a transient or persistent environmental stimulus. While it is well established that fibroblasts retain a memory of their anatomical location, how other environmental stimuli influence fibroblast behaviour and function is less clear. The ability of fibroblasts to respond and memorise different environmental stimuli is essential for tissue development and homeostasis and may become dysregulated in chronic disease conditions such as fibrosis and cancer. Here we summarise the four emerging key areas of fibroblast adaptation: positional, mechanical, inflammatory, and metabolic memory and highlight the underlying mechanisms and their implications in tissue homeostasis and disease.Thomas KirkAbubkr AhmedEmanuel RognoniMDPI AGarticlebiological memoryfibroblastswound healingfibrosiscancerinflammationBiology (General)QH301-705.5ENCells, Vol 10, Iss 2840, p 2840 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological memory fibroblasts wound healing fibrosis cancer inflammation Biology (General) QH301-705.5
spellingShingle	biological memory fibroblasts wound healing fibrosis cancer inflammation Biology (General) QH301-705.5 Thomas Kirk Abubkr Ahmed Emanuel Rognoni Fibroblast Memory in Development, Homeostasis and Disease
description	Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cell population that constantly responds and adapts to their environment. Biological memory is the process of a sustained altered cellular state and functions in response to a transient or persistent environmental stimulus. While it is well established that fibroblasts retain a memory of their anatomical location, how other environmental stimuli influence fibroblast behaviour and function is less clear. The ability of fibroblasts to respond and memorise different environmental stimuli is essential for tissue development and homeostasis and may become dysregulated in chronic disease conditions such as fibrosis and cancer. Here we summarise the four emerging key areas of fibroblast adaptation: positional, mechanical, inflammatory, and metabolic memory and highlight the underlying mechanisms and their implications in tissue homeostasis and disease.
format	article
author	Thomas Kirk Abubkr Ahmed Emanuel Rognoni
author_facet	Thomas Kirk Abubkr Ahmed Emanuel Rognoni
author_sort	Thomas Kirk
title	Fibroblast Memory in Development, Homeostasis and Disease
title_short	Fibroblast Memory in Development, Homeostasis and Disease
title_full	Fibroblast Memory in Development, Homeostasis and Disease
title_fullStr	Fibroblast Memory in Development, Homeostasis and Disease
title_full_unstemmed	Fibroblast Memory in Development, Homeostasis and Disease
title_sort	fibroblast memory in development, homeostasis and disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1669ef7116944a60947388ffd037489a
work_keys_str_mv	AT thomaskirk fibroblastmemoryindevelopmenthomeostasisanddisease AT abubkrahmed fibroblastmemoryindevelopmenthomeostasisanddisease AT emanuelrognoni fibroblastmemoryindevelopmenthomeostasisanddisease
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Fibroblast Memory in Development, Homeostasis and Disease

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