Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study

Abstract Individuals with dentofacial deformities often display a low quality of life (QoL) through biological mechanisms that remain unraveled. In this case–control study, the salivary levels of cytokines, glutamate, and kynurenine metabolites were assessed in patients undergoing orthognathic surge...

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Autores principales:	Maria C. C. Volkweis, Gabriela W. Neculqueo, Raquel D. S. Freitas, Ana P. A. Dagnino, Guilherme G. Fritscher, Tatiana Q. Irigaray, Maria M. Campos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/166c1e6036fe4a5baa970216b335abc7
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spelling	oai:doaj.org-article:166c1e6036fe4a5baa970216b335abc72021-12-02T15:49:50ZPsychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study10.1038/s41598-021-90721-62045-2322https://doaj.org/article/166c1e6036fe4a5baa970216b335abc72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90721-6https://doaj.org/toc/2045-2322Abstract Individuals with dentofacial deformities often display a low quality of life (QoL) through biological mechanisms that remain unraveled. In this case–control study, the salivary levels of cytokines, glutamate, and kynurenine metabolites were assessed in patients undergoing orthognathic surgery (OS), while correlating these parameters with QoL and psychological symptoms. Thirty-six patients were enrolled in control (under orthodontic treatment) and test (undergoing OS) groups, matched by age and sex. The QoL was assessed through the World Health Organization Quality of Life BREF (WHOQOL-BREF) and the Orthognathic Quality of Life Questionnaire (OQLQ). The psychological symptoms were evaluated by the Satisfaction with Life Scale, the Rosenberg Self-Esteem Scale (RSES), and the Depression, Anxiety, and Stress Scale-21 (DASS-21). The salivary levels of IL-1β, IL-6, IL-10, glutamate, and kynurenine metabolites were evaluated. The OQLQ demonstrated increased QoL scores in the test group, regarding social aspects, facial esthetics, and function domains, without significant differences in respect to the other surveys. These patients displayed higher IL-1β and glutamate levels; conversely, the kynurenine metabolites were unaltered. The glutamate levels positively correlated with the OQLQ function scores. The data brings novel evidence about the psychobiological features of patients with dentofacial deformities, showing salivary variations of inflammatory biomarkers in these individuals.Maria C. C. VolkweisGabriela W. NeculqueoRaquel D. S. FreitasAna P. A. DagninoGuilherme G. FritscherTatiana Q. IrigarayMaria M. CamposNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria C. C. Volkweis Gabriela W. Neculqueo Raquel D. S. Freitas Ana P. A. Dagnino Guilherme G. Fritscher Tatiana Q. Irigaray Maria M. Campos Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
description	Abstract Individuals with dentofacial deformities often display a low quality of life (QoL) through biological mechanisms that remain unraveled. In this case–control study, the salivary levels of cytokines, glutamate, and kynurenine metabolites were assessed in patients undergoing orthognathic surgery (OS), while correlating these parameters with QoL and psychological symptoms. Thirty-six patients were enrolled in control (under orthodontic treatment) and test (undergoing OS) groups, matched by age and sex. The QoL was assessed through the World Health Organization Quality of Life BREF (WHOQOL-BREF) and the Orthognathic Quality of Life Questionnaire (OQLQ). The psychological symptoms were evaluated by the Satisfaction with Life Scale, the Rosenberg Self-Esteem Scale (RSES), and the Depression, Anxiety, and Stress Scale-21 (DASS-21). The salivary levels of IL-1β, IL-6, IL-10, glutamate, and kynurenine metabolites were evaluated. The OQLQ demonstrated increased QoL scores in the test group, regarding social aspects, facial esthetics, and function domains, without significant differences in respect to the other surveys. These patients displayed higher IL-1β and glutamate levels; conversely, the kynurenine metabolites were unaltered. The glutamate levels positively correlated with the OQLQ function scores. The data brings novel evidence about the psychobiological features of patients with dentofacial deformities, showing salivary variations of inflammatory biomarkers in these individuals.
format	article
author	Maria C. C. Volkweis Gabriela W. Neculqueo Raquel D. S. Freitas Ana P. A. Dagnino Guilherme G. Fritscher Tatiana Q. Irigaray Maria M. Campos
author_facet	Maria C. C. Volkweis Gabriela W. Neculqueo Raquel D. S. Freitas Ana P. A. Dagnino Guilherme G. Fritscher Tatiana Q. Irigaray Maria M. Campos
author_sort	Maria C. C. Volkweis
title	Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
title_short	Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
title_full	Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
title_fullStr	Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
title_full_unstemmed	Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
title_sort	psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/166c1e6036fe4a5baa970216b335abc7
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Psychological symptoms and salivary inflammatory biomarkers in patients with dentofacial deformities: a case–control study

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