NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to induce a permissive epigenetic configuration of...

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Autores principales: Hanane Yahia-Cherbal, Magda Rybczynska, Domenica Lovecchio, Tharshana Stephen, Chloé Lescale, Katarzyna Placek, Jérome Larghero, Lars Rogge, Elisabetta Bianchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/166cd8254eb047cc9fc07933d1b96034
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spelling oai:doaj.org-article:166cd8254eb047cc9fc07933d1b960342021-12-02T17:01:31ZNFAT primes the human RORC locus for RORγt expression in CD4+ T cells10.1038/s41467-019-12680-x2041-1723https://doaj.org/article/166cd8254eb047cc9fc07933d1b960342019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12680-xhttps://doaj.org/toc/2041-1723The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to induce a permissive epigenetic configuration of the RORC gene for RORγt expression and Th17 differentiation.Hanane Yahia-CherbalMagda RybczynskaDomenica LovecchioTharshana StephenChloé LescaleKatarzyna PlacekJérome LargheroLars RoggeElisabetta BianchiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hanane Yahia-Cherbal
Magda Rybczynska
Domenica Lovecchio
Tharshana Stephen
Chloé Lescale
Katarzyna Placek
Jérome Larghero
Lars Rogge
Elisabetta Bianchi
NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
description The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to induce a permissive epigenetic configuration of the RORC gene for RORγt expression and Th17 differentiation.
format article
author Hanane Yahia-Cherbal
Magda Rybczynska
Domenica Lovecchio
Tharshana Stephen
Chloé Lescale
Katarzyna Placek
Jérome Larghero
Lars Rogge
Elisabetta Bianchi
author_facet Hanane Yahia-Cherbal
Magda Rybczynska
Domenica Lovecchio
Tharshana Stephen
Chloé Lescale
Katarzyna Placek
Jérome Larghero
Lars Rogge
Elisabetta Bianchi
author_sort Hanane Yahia-Cherbal
title NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
title_short NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
title_full NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
title_fullStr NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
title_full_unstemmed NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
title_sort nfat primes the human rorc locus for rorγt expression in cd4+ t cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/166cd8254eb047cc9fc07933d1b96034
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