NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

NFAT primes the human RORC locus for RORγt expression in CD4+ T cells

The master transcription factor RORγt, encoded by the RORC gene, controls the polarization of CD4+ T cells expressing interleukin-17 (Th17). Here the authors describe several regulatory elements at the RORC locus that are recognized by NFAT and NFkB to induce a permissive epigenetic configuration of...

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Autores principales: Hanane Yahia-Cherbal, Magda Rybczynska, Domenica Lovecchio, Tharshana Stephen, Chloé Lescale, Katarzyna Placek, Jérome Larghero, Lars Rogge, Elisabetta Bianchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/166cd8254eb047cc9fc07933d1b96034
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