The predictive value of serum level of cystatin C for COVID-19 severity

Abstract To investigate the potential prognostic value of Serum cystatin C (sCys C) in patients with COVID-19 and determine the association of sCys C with severe COVID-19 illness. We performed a retrospective review of medical records of 162 (61.7 ± 13.5 years) patients with COVID-19. We assessed th...

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Autores principales:	Luanfeng Lin, Xiaoling Chen, Junnian Chen, Xiaobin Pan, Pincang Xia, Hailong Lin, Houwei Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/166d167aa32447a09eff2d47a58a9ad8
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spelling	oai:doaj.org-article:166d167aa32447a09eff2d47a58a9ad82021-11-14T12:18:27ZThe predictive value of serum level of cystatin C for COVID-19 severity10.1038/s41598-021-01570-22045-2322https://doaj.org/article/166d167aa32447a09eff2d47a58a9ad82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01570-2https://doaj.org/toc/2045-2322Abstract To investigate the potential prognostic value of Serum cystatin C (sCys C) in patients with COVID-19 and determine the association of sCys C with severe COVID-19 illness. We performed a retrospective review of medical records of 162 (61.7 ± 13.5 years) patients with COVID-19. We assessed the predictive accuracy of sCys C for COVID-19 severity by the receiver operating characteristic (ROC) curve analysis. The participants were divided into two groups based on the sCys C cut-off value. We evaluated the association between high sCys C level and the development of severe COVID-19 disease, using a COX proportional hazards regression model. The area under the ROC curve was 0.708 (95% CI 0.594–0.822), the cut-off value was 1.245 (mg/L), and the sensitivity and specificity was 79.1% and 60.7%, respectively. A multivariable Cox analysis showed that a higher level of sCys C (adjusted HR 2.78 95% CI 1.25–6.18, p = 0.012) was significantly associated with an increased risk of developing a severe COVID-19 illness. Patients with a higher sCys C level have an increased risk of severe COVID-19 disease. Our findings suggest that early assessing sCys C could help to identify potential severe COVID-19 patients.Luanfeng LinXiaoling ChenJunnian ChenXiaobin PanPincang XiaHailong LinHouwei DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luanfeng Lin Xiaoling Chen Junnian Chen Xiaobin Pan Pincang Xia Hailong Lin Houwei Du The predictive value of serum level of cystatin C for COVID-19 severity
description	Abstract To investigate the potential prognostic value of Serum cystatin C (sCys C) in patients with COVID-19 and determine the association of sCys C with severe COVID-19 illness. We performed a retrospective review of medical records of 162 (61.7 ± 13.5 years) patients with COVID-19. We assessed the predictive accuracy of sCys C for COVID-19 severity by the receiver operating characteristic (ROC) curve analysis. The participants were divided into two groups based on the sCys C cut-off value. We evaluated the association between high sCys C level and the development of severe COVID-19 disease, using a COX proportional hazards regression model. The area under the ROC curve was 0.708 (95% CI 0.594–0.822), the cut-off value was 1.245 (mg/L), and the sensitivity and specificity was 79.1% and 60.7%, respectively. A multivariable Cox analysis showed that a higher level of sCys C (adjusted HR 2.78 95% CI 1.25–6.18, p = 0.012) was significantly associated with an increased risk of developing a severe COVID-19 illness. Patients with a higher sCys C level have an increased risk of severe COVID-19 disease. Our findings suggest that early assessing sCys C could help to identify potential severe COVID-19 patients.
format	article
author	Luanfeng Lin Xiaoling Chen Junnian Chen Xiaobin Pan Pincang Xia Hailong Lin Houwei Du
author_facet	Luanfeng Lin Xiaoling Chen Junnian Chen Xiaobin Pan Pincang Xia Hailong Lin Houwei Du
author_sort	Luanfeng Lin
title	The predictive value of serum level of cystatin C for COVID-19 severity
title_short	The predictive value of serum level of cystatin C for COVID-19 severity
title_full	The predictive value of serum level of cystatin C for COVID-19 severity
title_fullStr	The predictive value of serum level of cystatin C for COVID-19 severity
title_full_unstemmed	The predictive value of serum level of cystatin C for COVID-19 severity
title_sort	predictive value of serum level of cystatin c for covid-19 severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/166d167aa32447a09eff2d47a58a9ad8
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The predictive value of serum level of cystatin C for COVID-19 severity

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