Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

Abstract Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from...

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Autores principales:	Yueqiao Qu, Teng Ma, Youmin He, Mingyue Yu, Jiang Zhu, Yusi Miao, Cuixia Dai, Pranav Patel, K. Kirk Shung, Qifa Zhou, Zhongping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/166d83c47066433b88adddd88df0d459
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spelling	oai:doaj.org-article:166d83c47066433b88adddd88df0d4592021-12-02T15:05:10ZMiniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography10.1038/s41598-017-05077-72045-2322https://doaj.org/article/166d83c47066433b88adddd88df0d4592017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05077-7https://doaj.org/toc/2045-2322Abstract Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial tissue. We report the development of an acoustic radiation force optical coherence elastography (ARF-OCE) system that uses an integrated miniature ultrasound and optical coherence tomography (OCT) probe to map the relative elasticity of vascular tissues. We demonstrate the capability of the miniature probe to map the biomechanical properties in phantom and human cadaver carotid arteries.Yueqiao QuTeng MaYoumin HeMingyue YuJiang ZhuYusi MiaoCuixia DaiPranav PatelK. Kirk ShungQifa ZhouZhongping ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yueqiao Qu Teng Ma Youmin He Mingyue Yu Jiang Zhu Yusi Miao Cuixia Dai Pranav Patel K. Kirk Shung Qifa Zhou Zhongping Chen Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
description	Abstract Cardiovascular diseases are the leading cause of fatalities in the United States. Atherosclerotic plaques are one of the primary complications that can lead to strokes and heart attacks if left untreated. It is essential to diagnose the disease early and distinguish vulnerable plaques from harmless ones. Many methods focus on the structural or molecular properties of plaques. Mechanical properties have been shown to change drastically when abnormalities develop in arterial tissue. We report the development of an acoustic radiation force optical coherence elastography (ARF-OCE) system that uses an integrated miniature ultrasound and optical coherence tomography (OCT) probe to map the relative elasticity of vascular tissues. We demonstrate the capability of the miniature probe to map the biomechanical properties in phantom and human cadaver carotid arteries.
format	article
author	Yueqiao Qu Teng Ma Youmin He Mingyue Yu Jiang Zhu Yusi Miao Cuixia Dai Pranav Patel K. Kirk Shung Qifa Zhou Zhongping Chen
author_facet	Yueqiao Qu Teng Ma Youmin He Mingyue Yu Jiang Zhu Yusi Miao Cuixia Dai Pranav Patel K. Kirk Shung Qifa Zhou Zhongping Chen
author_sort	Yueqiao Qu
title	Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
title_short	Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
title_full	Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
title_fullStr	Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
title_full_unstemmed	Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
title_sort	miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/166d83c47066433b88adddd88df0d459
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_version_	1718388876041519104

Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography

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