Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

Código QR

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

Using phasor-FLIM (Fluorescence Lifetime Imaging Microscopy), Wang et al. reveal differential usages of oxidative phosphorylation and glycolysis in living islet cells following glucose stimulation. This study suggests the applicability of FLIM as a drug discovery tool as it reports perturbations in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhongying Wang, Tatyana Gurlo, Aleksey V. Matveyenko, David Elashoff, Peiyu Wang, Madeline Rosenberger, Jason A. Junge, Raymond C. Stevens, Kate L. White, Scott E. Fraser, Peter C. Butler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/16706c9faa644994ba8974540e742fe0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Role of myeloid cell leptin signaling in the regulation of glucose metabolism
por: Sandra Pereira, et al.
Publicado: (2021)

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
por: Seung-Chul Choi, et al.
Publicado: (2018)

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress
por: Nam Hee Kim, et al.
Publicado: (2017)

Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression
por: Laura Brohée, et al.
Publicado: (2018)

Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells
por: Ratnasekhar Ch, et al.
Publicado: (2021)

Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism
por: Ekaterina E. Bibik, et al.
Publicado: (2021)

New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
por: Eva Gottfried, et al.
Publicado: (2013)

Analysis of glucose metabolism by 18F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage
por: Xiaoning Han, et al.
Publicado: (2021)

Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions.
por: Yuta Shinohara, et al.
Publicado: (2021)

Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions
por: Yuta Shinohara, et al.
Publicado: (2021)

Neuronal control of peripheral insulin sensitivity and glucose metabolism
por: Johan Ruud, et al.
Publicado: (2017)

High glucose induced c-Met activation promotes aggressive phenotype and regulates expression of glucose metabolism genes in HCC cells
por: Hande Topel, et al.
Publicado: (2021)

Gis1 and Rph1 regulate glycerol and acetate metabolism in glucose depleted yeast cells.
por: Jakub Orzechowski Westholm, et al.
Publicado: (2012)

Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells
por: Abdelnour H. Alhourani, et al.
Publicado: (2021)

Transcriptional profiles of human islet and exocrine endothelial cells in subjects with or without impaired glucose metabolism
por: Alexander Jonsson, et al.
Publicado: (2020)

Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species
por: Lee MJ, et al.
Publicado: (2015)

Mechanisms of transcriptional control of glucose metabolism in hepatocytes
por: Konstantin Y. Kulebyakin, et al.
Publicado: (2016)

Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
por: Xin Su, et al.
Publicado: (2021)

Architectural control of metabolic plasticity in epithelial cancer cells
por: Maia Al-Masri, et al.
Publicado: (2021)

Estrogen Regulates Glucose Metabolism in Cattle Neutrophils Through Autophagy
por: Xinbo Wang, et al.
Publicado: (2021)

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
por: Rodrigo Carlessi, et al.
Publicado: (2017)

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
por: Chiara Montemurro, et al.
Publicado: (2019)

Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients
por: Buxton OM, et al.
Publicado: (2017)

Effects of exogenous α-(1,4)-amylase on the utilisation of corn starch and glucose metabolism in broiler chickens
por: H. Zhou, et al.
Publicado: (2021)

Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
por: Ming-Liang Lee, et al.
Publicado: (2021)

High-intensity infrasound effects on glucose metabolism in rats
por: Gonçalo Martins Pereira, et al.
Publicado: (2021)

Enzymes of an alternative pathway of glucose metabolism in obligate methanotrophs
por: Olga N. Rozova, et al.
Publicado: (2021)

Sex Differences in the Effect of Diabetes on Cerebral Glucose Metabolism
por: Chun-Yi Wu, et al.
Publicado: (2021)

Glucose Metabolism in Acute Kidney Injury and Kidney Repair
por: Lu Wen, et al.
Publicado: (2021)

The bone hormones and their potential effects on glucose and energy metabolism
por: Addai Daniel, et al.
Publicado: (2019)

SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
por: I. D. Bespalovа, et al.
Publicado: (2014)

Effect of linagliptin on glucose metabolism and pancreatic beta cell function in patients with persistent prediabetes after metformin and lifestyle
por: Mildred Fátima de la Luz Alvarez-Canales, et al.
Publicado: (2021)

Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia.
por: Charlotte J Green, et al.
Publicado: (2012)

Publisher Correction: IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
por: Chiara Montemurro, et al.
Publicado: (2019)

Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
por: Rodrigo Fernández-Verdejo, et al.
Publicado: (2021)

PA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes
por: Cuizhe Wang, et al.
Publicado: (2021)

Cell size and basal metabolic rate in hummingbirds
por: Opazo,Juan C., et al.
Publicado: (2005)

Metabolic signatures in the conversion from gestational diabetes mellitus to postpartum abnormal glucose metabolism: a pilot study in Asian women
por: Xi-Meng Wang, et al.
Publicado: (2021)

E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
por: Theodore A. Chavkin, et al.
Publicado: (2021)

Glycerol suppresses glucose consumption in trypanosomes through metabolic contest.
por: Stefan Allmann, et al.
Publicado: (2021)