Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel

Ahmad M Eid, Ibraheem Istateyeh, Noura Salhi, Thaer Istateyeh Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, PalestineCorrespondence: Ahmad M EidPharmaceutical Chemistry and Technology Division, Department of Pharmacy, Faculty of Medicine and H...

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Autores principales:	Eid AM, Istateyeh I, Salhi N, Istateyeh T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	fusidic acid sodium fusidate nanoemulgel pine oil antibacterial activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1671475495134fe886bde338f4555139
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spelling	oai:doaj.org-article:1671475495134fe886bde338f45551392021-12-02T06:20:52ZAntibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel1178-2013https://doaj.org/article/1671475495134fe886bde338f45551392019-12-01T00:00:00Zhttps://www.dovepress.com/antibacterial-activity-of-fusidic-acid-and-sodium-fusidate-nanoparticl-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ahmad M Eid, Ibraheem Istateyeh, Noura Salhi, Thaer Istateyeh Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, PalestineCorrespondence: Ahmad M EidPharmaceutical Chemistry and Technology Division, Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, PalestineEmail ahmadeid@najah.eduPurpose: Fusidic acid (FA) and sodium fusidate (SF) have problems in their skin penetration and stability resulting in a reduction in their potency; therefore, the objective of this study was to develop FA and SF nanoemulgels to improve the antibacterial activity of the drugs.Methods: FA and SF nanoemulgel formulations were prepared by the incorporation of FA and SF nanoemulsions with Carbopol hydrogel. First, the drugs were screened for their solubility in different oils and surfactants to choose the suitable oil and surfactants for the drugs, and then the drug nanoemulsion formulations were prepared by a self-nanoemulsifying technique using Tween 80, Span 20 and pine oil. The drug nanoemulgels were evaluated for their particle size, polydispersity index (PDI), rheological behaviour, drug release and anti-microbial activity.Results: Based on the solubility test, pine oil was the best solubilising oil for both drugs, Tween 80 and Span 20 showed the highest solubilising ability for both the drugs among the surfactants; therefore, they were chosen as surfactant and co-surfactant, respectively. The optimum self-nanoemulsifying formulations showed a particle size for fusidic acid and Sodium fusidate of 140.58 nm and 151.86 nm respectively, and both showed a low PDI below 0.3. After incorporating both drug SNEDDS formulations with Carbopol at different concentrations, the results of the drugs particle size and PDI showed no significant difference. The zeta potential results for both drugs nanoemulgels showed a negative potential with more than 30 mV. All nanoemulgel formulations showed pseudo-plastic behaviour with the highest release pattern at 0.4% Carbopol. The antibacterial activity of both drug nanoemulgel formulations showed superiority over the market product.Conclusion: Nanoemulgel is a promising delivery system for FA and SF that helps in improving the stability and antibacterial activities of the drugs.Keywords: fusidic acid, sodium fusidate, nanoemulgel, pine oil, antibacterial activityEid AMIstateyeh ISalhi NIstateyeh TDove Medical Pressarticlefusidic acidsodium fusidatenanoemulgelpine oilantibacterial activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9411-9421 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fusidic acid sodium fusidate nanoemulgel pine oil antibacterial activity Medicine (General) R5-920
spellingShingle	fusidic acid sodium fusidate nanoemulgel pine oil antibacterial activity Medicine (General) R5-920 Eid AM Istateyeh I Salhi N Istateyeh T Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
description	Ahmad M Eid, Ibraheem Istateyeh, Noura Salhi, Thaer Istateyeh Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, PalestineCorrespondence: Ahmad M EidPharmaceutical Chemistry and Technology Division, Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, PalestineEmail ahmadeid@najah.eduPurpose: Fusidic acid (FA) and sodium fusidate (SF) have problems in their skin penetration and stability resulting in a reduction in their potency; therefore, the objective of this study was to develop FA and SF nanoemulgels to improve the antibacterial activity of the drugs.Methods: FA and SF nanoemulgel formulations were prepared by the incorporation of FA and SF nanoemulsions with Carbopol hydrogel. First, the drugs were screened for their solubility in different oils and surfactants to choose the suitable oil and surfactants for the drugs, and then the drug nanoemulsion formulations were prepared by a self-nanoemulsifying technique using Tween 80, Span 20 and pine oil. The drug nanoemulgels were evaluated for their particle size, polydispersity index (PDI), rheological behaviour, drug release and anti-microbial activity.Results: Based on the solubility test, pine oil was the best solubilising oil for both drugs, Tween 80 and Span 20 showed the highest solubilising ability for both the drugs among the surfactants; therefore, they were chosen as surfactant and co-surfactant, respectively. The optimum self-nanoemulsifying formulations showed a particle size for fusidic acid and Sodium fusidate of 140.58 nm and 151.86 nm respectively, and both showed a low PDI below 0.3. After incorporating both drug SNEDDS formulations with Carbopol at different concentrations, the results of the drugs particle size and PDI showed no significant difference. The zeta potential results for both drugs nanoemulgels showed a negative potential with more than 30 mV. All nanoemulgel formulations showed pseudo-plastic behaviour with the highest release pattern at 0.4% Carbopol. The antibacterial activity of both drug nanoemulgel formulations showed superiority over the market product.Conclusion: Nanoemulgel is a promising delivery system for FA and SF that helps in improving the stability and antibacterial activities of the drugs.Keywords: fusidic acid, sodium fusidate, nanoemulgel, pine oil, antibacterial activity
format	article
author	Eid AM Istateyeh I Salhi N Istateyeh T
author_facet	Eid AM Istateyeh I Salhi N Istateyeh T
author_sort	Eid AM
title	Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
title_short	Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
title_full	Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
title_fullStr	Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
title_full_unstemmed	Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel
title_sort	antibacterial activity of fusidic acid and sodium fusidate nanoparticles incorporated in pine oil nanoemulgel
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/1671475495134fe886bde338f4555139
work_keys_str_mv	AT eidam antibacterialactivityoffusidicacidandsodiumfusidatenanoparticlesincorporatedinpineoilnanoemulgel AT istateyehi antibacterialactivityoffusidicacidandsodiumfusidatenanoparticlesincorporatedinpineoilnanoemulgel AT salhin antibacterialactivityoffusidicacidandsodiumfusidatenanoparticlesincorporatedinpineoilnanoemulgel AT istateyeht antibacterialactivityoffusidicacidandsodiumfusidatenanoparticlesincorporatedinpineoilnanoemulgel
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Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel

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