Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection

Muluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically ac...

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Autor principal:	Ademe M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mdscs phenotype hiv art therapeutic targets paradox Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1672dbde12ed46078e79b496ba1394ad
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spelling	oai:doaj.org-article:1672dbde12ed46078e79b496ba1394ad2021-12-02T12:03:52ZParadoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection1179-1373https://doaj.org/article/1672dbde12ed46078e79b496ba1394ad2020-04-01T00:00:00Zhttps://www.dovepress.com/paradoxes-in-the-phenotype-frequency-and-roles-of-myeloid-derived-supp-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Muluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically activated myeloid cells with potent immunosuppressive function. Due to their role in negatively regulating the immune system, MDSCs have been strongly correlated with disease progression during HIV. However, findings vary considerably between studies. The dominant phenotype of MDSC subsets during HIV is not well ascertained. Moreover, there is no clear understanding on the clinical significance of MDSCs during HIV infection. The existing evidences showed the double-sided roles of MDSCs in HIV. On the one hand, MDSCs are linked to deleterious effects during HIV infection as they inhibit proliferation of protective T cell response. On the other hand, the immunosuppressive abilities of MDSCs were shown to be beneficial in curbing the damaging effects of persistent immune activation associated with chronic HIV infection. Therefore, this review aimed to describe the differences in the existing literatures pertaining to the phenotype, frequency and roles of MDSCs during HIV infection.Keywords: MDSCs, phenotype, HIV, ART, therapeutic targets, paradoxAdeme MDove Medical Pressarticlemdscsphenotypehivarttherapeutic targetsparadoxImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 151-156 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mdscs phenotype hiv art therapeutic targets paradox Immunologic diseases. Allergy RC581-607
spellingShingle	mdscs phenotype hiv art therapeutic targets paradox Immunologic diseases. Allergy RC581-607 Ademe M Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
description	Muluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically activated myeloid cells with potent immunosuppressive function. Due to their role in negatively regulating the immune system, MDSCs have been strongly correlated with disease progression during HIV. However, findings vary considerably between studies. The dominant phenotype of MDSC subsets during HIV is not well ascertained. Moreover, there is no clear understanding on the clinical significance of MDSCs during HIV infection. The existing evidences showed the double-sided roles of MDSCs in HIV. On the one hand, MDSCs are linked to deleterious effects during HIV infection as they inhibit proliferation of protective T cell response. On the other hand, the immunosuppressive abilities of MDSCs were shown to be beneficial in curbing the damaging effects of persistent immune activation associated with chronic HIV infection. Therefore, this review aimed to describe the differences in the existing literatures pertaining to the phenotype, frequency and roles of MDSCs during HIV infection.Keywords: MDSCs, phenotype, HIV, ART, therapeutic targets, paradox
format	article
author	Ademe M
author_facet	Ademe M
author_sort	Ademe M
title	Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
title_short	Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
title_full	Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
title_fullStr	Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
title_full_unstemmed	Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
title_sort	paradoxes in the phenotype, frequency and roles of myeloid-derived suppressor cells during hiv infection
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1672dbde12ed46078e79b496ba1394ad
work_keys_str_mv	AT ademem paradoxesinthephenotypefrequencyandrolesofmyeloidderivedsuppressorcellsduringhivinfection
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Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection

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