Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.

Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, a two-group classification in patients...

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Autores principales:	Marta Subirà, Pino Alonso, Cinto Segalàs, Eva Real, Clara López-Solà, Jesús Pujol, Ignacio Martínez-Zalacaín, Ben J Harrison, José M Menchón, Narcís Cardoner, Carles Soriano-Mas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1676d3969a1949e6b7fed8c111616c5f
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spelling	oai:doaj.org-article:1676d3969a1949e6b7fed8c111616c5f2021-11-18T08:53:10ZBrain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.1932-620310.1371/journal.pone.0075273https://doaj.org/article/1676d3969a1949e6b7fed8c111616c5f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24098688/?tool=EBIhttps://doaj.org/toc/1932-6203Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, a two-group classification in patients with autogenous and reactive obsessions has been proposed. The purpose of the present study was to assess, by means of a voxel-based morphometry analysis, the putative brain structural correlates of this classification scheme in OCD patients. Ninety-five OCD patients and 95 healthy controls were recruited. Patients were divided into autogenous (n = 30) and reactive (n = 65) sub-groups. A structural magnetic resonance image was acquired for each participant and pre-processed with SPM8 software to obtain a volume-modulated gray matter map. Whole-brain and voxel-wise comparisons between the study groups were then performed. In comparison to the autogenous group, reactive patients showed larger gray matter volumes in the right Rolandic operculum. When compared to healthy controls, reactive patients showed larger volumes in the putamen (bilaterally), while autogenous patients showed a smaller left anterior temporal lobe. Also in comparison to healthy controls, the right middle temporal gyrus was smaller in both patient subgroups. Our results suggest that autogenous and reactive obsessions depend on partially dissimilar neural substrates. Our findings provide some neurobiological support for this classification scheme and contribute to unraveling the neurobiological basis of clinical heterogeneity in OCD.Marta SubiràPino AlonsoCinto SegalàsEva RealClara López-SolàJesús PujolIgnacio Martínez-ZalacaínBen J HarrisonJosé M MenchónNarcís CardonerCarles Soriano-MasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75273 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Subirà Pino Alonso Cinto Segalàs Eva Real Clara López-Solà Jesús Pujol Ignacio Martínez-Zalacaín Ben J Harrison José M Menchón Narcís Cardoner Carles Soriano-Mas Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
description	Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, a two-group classification in patients with autogenous and reactive obsessions has been proposed. The purpose of the present study was to assess, by means of a voxel-based morphometry analysis, the putative brain structural correlates of this classification scheme in OCD patients. Ninety-five OCD patients and 95 healthy controls were recruited. Patients were divided into autogenous (n = 30) and reactive (n = 65) sub-groups. A structural magnetic resonance image was acquired for each participant and pre-processed with SPM8 software to obtain a volume-modulated gray matter map. Whole-brain and voxel-wise comparisons between the study groups were then performed. In comparison to the autogenous group, reactive patients showed larger gray matter volumes in the right Rolandic operculum. When compared to healthy controls, reactive patients showed larger volumes in the putamen (bilaterally), while autogenous patients showed a smaller left anterior temporal lobe. Also in comparison to healthy controls, the right middle temporal gyrus was smaller in both patient subgroups. Our results suggest that autogenous and reactive obsessions depend on partially dissimilar neural substrates. Our findings provide some neurobiological support for this classification scheme and contribute to unraveling the neurobiological basis of clinical heterogeneity in OCD.
format	article
author	Marta Subirà Pino Alonso Cinto Segalàs Eva Real Clara López-Solà Jesús Pujol Ignacio Martínez-Zalacaín Ben J Harrison José M Menchón Narcís Cardoner Carles Soriano-Mas
author_facet	Marta Subirà Pino Alonso Cinto Segalàs Eva Real Clara López-Solà Jesús Pujol Ignacio Martínez-Zalacaín Ben J Harrison José M Menchón Narcís Cardoner Carles Soriano-Mas
author_sort	Marta Subirà
title	Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
title_short	Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
title_full	Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
title_fullStr	Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
title_full_unstemmed	Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
title_sort	brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1676d3969a1949e6b7fed8c111616c5f
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Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions.

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