Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond

Cross-coupling processes without the use of transition metals are challenging to achieve. Here, the authors show a transition-metal-free cross-coupling utilizing aryl(heteroaryl) methyl sulfoxides and alcohols to afford alkyl aryl(heteroaryl) ethers and propose a nucleophilic addition mechanism base...

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Autores principales:	Guolin Li, Yexenia Nieves-Quinones, Hui Zhang, Qingjin Liang, Shuaisong Su, Qingchao Liu, Marisa C. Kozlowski, Tiezheng Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1679d5adbdd047cb86a6aaee0fff8c7d
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spelling	oai:doaj.org-article:1679d5adbdd047cb86a6aaee0fff8c7d2021-12-02T14:58:13ZTransition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond10.1038/s41467-020-16713-82041-1723https://doaj.org/article/1679d5adbdd047cb86a6aaee0fff8c7d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16713-8https://doaj.org/toc/2041-1723Cross-coupling processes without the use of transition metals are challenging to achieve. Here, the authors show a transition-metal-free cross-coupling utilizing aryl(heteroaryl) methyl sulfoxides and alcohols to afford alkyl aryl(heteroaryl) ethers and propose a nucleophilic addition mechanism based on experiments and theory.Guolin LiYexenia Nieves-QuinonesHui ZhangQingjin LiangShuaisong SuQingchao LiuMarisa C. KozlowskiTiezheng JiaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guolin Li Yexenia Nieves-Quinones Hui Zhang Qingjin Liang Shuaisong Su Qingchao Liu Marisa C. Kozlowski Tiezheng Jia Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
description	Cross-coupling processes without the use of transition metals are challenging to achieve. Here, the authors show a transition-metal-free cross-coupling utilizing aryl(heteroaryl) methyl sulfoxides and alcohols to afford alkyl aryl(heteroaryl) ethers and propose a nucleophilic addition mechanism based on experiments and theory.
format	article
author	Guolin Li Yexenia Nieves-Quinones Hui Zhang Qingjin Liang Shuaisong Su Qingchao Liu Marisa C. Kozlowski Tiezheng Jia
author_facet	Guolin Li Yexenia Nieves-Quinones Hui Zhang Qingjin Liang Shuaisong Su Qingchao Liu Marisa C. Kozlowski Tiezheng Jia
author_sort	Guolin Li
title	Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
title_short	Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
title_full	Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
title_fullStr	Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
title_full_unstemmed	Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond
title_sort	transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of c-s bond
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1679d5adbdd047cb86a6aaee0fff8c7d
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Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond

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