Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory,...

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Autores principales:	Naoya Tanabe, Toyohiro Hirai
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	airway obstruction tomography x-ray computed pulmonary disease chronic obstructive pathology emphysema Medicine R
Acceso en línea:	https://doaj.org/article/167aff67e9274242a842a6cc2b29eee6
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spelling	oai:doaj.org-article:167aff67e9274242a842a6cc2b29eee62021-11-08T00:59:06ZRecent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease1226-33032005-664810.3904/kjim.2021.124https://doaj.org/article/167aff67e9274242a842a6cc2b29eee62021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2021-124.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory, terminal, and preterminal bronchioles to the central segmental airways. Although clinical computed tomography (CT) cannot be used to visualize the small airways, micro-CT has shown that terminal bronchiole disease is more severe in CLE than in PSE and PLE, and micro-CT findings suggest that the loss and luminal narrowing of terminal bronchioles is an early pathological change in CLE. Furthermore, the introduction of ultra-high-resolution CT has enabled direct evaluation of the proximal small (1 to 2-mm diameter) airways, and new CT analytical methods have enabled estimation of small airway disease and prediction of future COPD onset and lung function decline in smokers with and without COPD. This review discusses the literature on micro-CT and the technical advancements in clinical CT analysis for COPD. Hopefully, novel micro-CT findings will improve our understanding of the distinct pathogeneses of the emphysema subtypes to enable exploration of new therapeutic targets, and sophisticated CT imaging methods will be integrated into clinical practice to achieve more personalized management.Naoya TanabeToyohiro HiraiThe Korean Association of Internal Medicinearticleairway obstructiontomographyx-ray computedpulmonary diseasechronic obstructivepathologyemphysemaMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1294-1304 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	airway obstruction tomography x-ray computed pulmonary disease chronic obstructive pathology emphysema Medicine R
spellingShingle	airway obstruction tomography x-ray computed pulmonary disease chronic obstructive pathology emphysema Medicine R Naoya Tanabe Toyohiro Hirai Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
description	Chronic obstructive pulmonary disease (COPD) is a complex lung disease characterized by a combination of airway disease and emphysema. Emphysema is classified as centrilobular emphysema (CLE), paraseptal emphysema (PSE), or panlobular emphysema (PLE), and airway disease extends from the respiratory, terminal, and preterminal bronchioles to the central segmental airways. Although clinical computed tomography (CT) cannot be used to visualize the small airways, micro-CT has shown that terminal bronchiole disease is more severe in CLE than in PSE and PLE, and micro-CT findings suggest that the loss and luminal narrowing of terminal bronchioles is an early pathological change in CLE. Furthermore, the introduction of ultra-high-resolution CT has enabled direct evaluation of the proximal small (1 to 2-mm diameter) airways, and new CT analytical methods have enabled estimation of small airway disease and prediction of future COPD onset and lung function decline in smokers with and without COPD. This review discusses the literature on micro-CT and the technical advancements in clinical CT analysis for COPD. Hopefully, novel micro-CT findings will improve our understanding of the distinct pathogeneses of the emphysema subtypes to enable exploration of new therapeutic targets, and sophisticated CT imaging methods will be integrated into clinical practice to achieve more personalized management.
format	article
author	Naoya Tanabe Toyohiro Hirai
author_facet	Naoya Tanabe Toyohiro Hirai
author_sort	Naoya Tanabe
title	Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
title_short	Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
title_full	Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
title_fullStr	Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
title_full_unstemmed	Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
title_sort	recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/167aff67e9274242a842a6cc2b29eee6
work_keys_str_mv	AT naoyatanabe recentadvancesinairwayimagingusingmicrocomputedtomographyandcomputedtomographyforchronicobstructivepulmonarydisease AT toyohirohirai recentadvancesinairwayimagingusingmicrocomputedtomographyandcomputedtomographyforchronicobstructivepulmonarydisease
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Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease

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