Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population

Abstract Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: B...

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Autores principales:	Min Mu, Li Jing, Yuan-Jie Zou, Xing-Rong Tao, Fei Wang, Jun Lu
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	Tuberculosis; ELOVL2 gene Single nucleotide polymorphism China Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/167c9c0891a048698b52f73846265190
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spelling	oai:doaj.org-article:167c9c0891a048698b52f738462651902021-12-02T17:09:48ZPolymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population2251-60852251-6093https://doaj.org/article/167c9c0891a048698b52f738462651902021-10-01T00:00:00Zhttps://ijph.tums.ac.ir/index.php/ijph/article/view/25429https://doaj.org/toc/2251-6085https://doaj.org/toc/2251-6093 Abstract Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. Results: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, OR = 1.414, 95% CI: 1.036-1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, OR = 0.507; 95% CI: 0.262-0.981, P < 0.05). Conclusion: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients. Min MuLi JingYuan-Jie ZouXing-Rong TaoFei WangJun LuTehran University of Medical SciencesarticleTuberculosis; ELOVL2 geneSingle nucleotide polymorphismChinaPublic aspects of medicineRA1-1270ENIranian Journal of Public Health, Vol 50, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tuberculosis; ELOVL2 gene Single nucleotide polymorphism China Public aspects of medicine RA1-1270
spellingShingle	Tuberculosis; ELOVL2 gene Single nucleotide polymorphism China Public aspects of medicine RA1-1270 Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
description	Abstract Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. Results: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, OR = 1.414, 95% CI: 1.036-1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, OR = 0.507; 95% CI: 0.262-0.981, P < 0.05). Conclusion: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients.
format	article
author	Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu
author_facet	Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu
author_sort	Min Mu
title	Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_short	Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_full	Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_fullStr	Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_full_unstemmed	Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
title_sort	polymorphisms of fatty acid elongase 2 gene afftects risk of pulmonary tuberculosis in china han population
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/167c9c0891a048698b52f73846265190
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Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population

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