Sudden sensorineural hearing loss in patients with vestibular schwannoma

Abstract Clinical features of sudden sensorineural hearing loss (SSNHL) associated with vestibular schwannoma (VS) are not fully understood. Determining a treatment plan and explaining it to patients requires clinicians to clearly understand the clinical features related to the tumor, including SSNH...

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Autores principales:	Koichiro Wasano, Naoki Oishi, Masaru Noguchi, Ko Hentona, Seiichi Shinden, Tsubasa Kitama, Nobuyoshi Tsuzuki, Taiji Kawasaki, Yoshihiko Hiraga, Yasuhiko Takei, Kaoru Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/167ed897ec6549adaf16c70f91ad8e31
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spelling	oai:doaj.org-article:167ed897ec6549adaf16c70f91ad8e312021-12-02T14:07:47ZSudden sensorineural hearing loss in patients with vestibular schwannoma10.1038/s41598-020-80366-22045-2322https://doaj.org/article/167ed897ec6549adaf16c70f91ad8e312021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80366-2https://doaj.org/toc/2045-2322Abstract Clinical features of sudden sensorineural hearing loss (SSNHL) associated with vestibular schwannoma (VS) are not fully understood. Determining a treatment plan and explaining it to patients requires clinicians to clearly understand the clinical features related to the tumor, including SSNHL. To identify the full range of clinical features of VS-associated SSNHL, especially recovery of hearing following multiple episodes of SSNHL and what factors predict recovery and recurrence. A multicenter retrospective chart review was conducted in seven tertiary care hospitals between April 1, 2011, and March 31, 2020. We collected and analyzed dose of administered steroid, pure-tone audiometry results, and brain MRIs of patients diagnosed with VS-associated SSNHL. Seventy-seven patients were included. They experienced 109 episodes of audiogram-confirmed SSNHL. The highest proportion of complete recoveries occurred in patients with U-shaped audiograms. The recovery rates for the first, second, and third and subsequent episodes of SSNHL were 53.5%, 28.0%, and 9.1%, respectively. Recovery rate decreased significantly with increasing number of SSNHL episodes (P =0 .0011; Cochran-Armitage test). After the first episode of SSNHL, the recurrence-free rate was 69.9% over 1 year and 57.7% over 2 years; the median recurrence time was 32 months. Logarithmic approximation revealed that there is a 25% probability that SSNHL would recur within a year. SSNHL in patients with VS is likely to recur within one year in 25% of cases. Also, recovery rate decreases as a patient experiences increasing episodes of SSNHL.Koichiro WasanoNaoki OishiMasaru NoguchiKo HentonaSeiichi ShindenTsubasa KitamaNobuyoshi TsuzukiTaiji KawasakiYoshihiko HiragaYasuhiko TakeiKaoru OgawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koichiro Wasano Naoki Oishi Masaru Noguchi Ko Hentona Seiichi Shinden Tsubasa Kitama Nobuyoshi Tsuzuki Taiji Kawasaki Yoshihiko Hiraga Yasuhiko Takei Kaoru Ogawa Sudden sensorineural hearing loss in patients with vestibular schwannoma
description	Abstract Clinical features of sudden sensorineural hearing loss (SSNHL) associated with vestibular schwannoma (VS) are not fully understood. Determining a treatment plan and explaining it to patients requires clinicians to clearly understand the clinical features related to the tumor, including SSNHL. To identify the full range of clinical features of VS-associated SSNHL, especially recovery of hearing following multiple episodes of SSNHL and what factors predict recovery and recurrence. A multicenter retrospective chart review was conducted in seven tertiary care hospitals between April 1, 2011, and March 31, 2020. We collected and analyzed dose of administered steroid, pure-tone audiometry results, and brain MRIs of patients diagnosed with VS-associated SSNHL. Seventy-seven patients were included. They experienced 109 episodes of audiogram-confirmed SSNHL. The highest proportion of complete recoveries occurred in patients with U-shaped audiograms. The recovery rates for the first, second, and third and subsequent episodes of SSNHL were 53.5%, 28.0%, and 9.1%, respectively. Recovery rate decreased significantly with increasing number of SSNHL episodes (P =0 .0011; Cochran-Armitage test). After the first episode of SSNHL, the recurrence-free rate was 69.9% over 1 year and 57.7% over 2 years; the median recurrence time was 32 months. Logarithmic approximation revealed that there is a 25% probability that SSNHL would recur within a year. SSNHL in patients with VS is likely to recur within one year in 25% of cases. Also, recovery rate decreases as a patient experiences increasing episodes of SSNHL.
format	article
author	Koichiro Wasano Naoki Oishi Masaru Noguchi Ko Hentona Seiichi Shinden Tsubasa Kitama Nobuyoshi Tsuzuki Taiji Kawasaki Yoshihiko Hiraga Yasuhiko Takei Kaoru Ogawa
author_facet	Koichiro Wasano Naoki Oishi Masaru Noguchi Ko Hentona Seiichi Shinden Tsubasa Kitama Nobuyoshi Tsuzuki Taiji Kawasaki Yoshihiko Hiraga Yasuhiko Takei Kaoru Ogawa
author_sort	Koichiro Wasano
title	Sudden sensorineural hearing loss in patients with vestibular schwannoma
title_short	Sudden sensorineural hearing loss in patients with vestibular schwannoma
title_full	Sudden sensorineural hearing loss in patients with vestibular schwannoma
title_fullStr	Sudden sensorineural hearing loss in patients with vestibular schwannoma
title_full_unstemmed	Sudden sensorineural hearing loss in patients with vestibular schwannoma
title_sort	sudden sensorineural hearing loss in patients with vestibular schwannoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/167ed897ec6549adaf16c70f91ad8e31
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Sudden sensorineural hearing loss in patients with vestibular schwannoma

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