Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.

Opioid substitution and syringes exchange programs have drastically reduced hepatitis C virus (HCV) spread in France but HCV sexual transmission in men having sex with men (MSM) has recently arisen as a significant public health concern. The fact that the virus is transmitting in a heterogeneous pop...

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Autores principales:	Gonché Danesh, Victor Virlogeux, Christophe Ramière, Caroline Charre, Laurent Cotte, Samuel Alizon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/168111c9bb4d4a738bd7ac2d3f43e650
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spelling	oai:doaj.org-article:168111c9bb4d4a738bd7ac2d3f43e6502021-12-02T20:00:11ZQuantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.1553-73661553-737410.1371/journal.ppat.1009916https://doaj.org/article/168111c9bb4d4a738bd7ac2d3f43e6502021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009916https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Opioid substitution and syringes exchange programs have drastically reduced hepatitis C virus (HCV) spread in France but HCV sexual transmission in men having sex with men (MSM) has recently arisen as a significant public health concern. The fact that the virus is transmitting in a heterogeneous population, with different transmission routes, makes prevalence and incidence rates poorly informative. However, additional insights can be gained by analyzing virus phylogenies inferred from dated genetic sequence data. By combining a phylodynamics approach based on Approximate Bayesian Computation (ABC) and an original transmission model, we estimate key epidemiological parameters of an ongoing HCV epidemic among MSMs in Lyon (France). We show that this new epidemic is largely independent of the previously observed non-MSM HCV epidemics and that its doubling time is ten times lower (0.44 years versus 4.37 years). These results have practical implications for HCV control and illustrate the additional information provided by virus genomics in public health.Gonché DaneshVictor VirlogeuxChristophe RamièreCaroline CharreLaurent CotteSamuel AlizonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 9, p e1009916 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Gonché Danesh Victor Virlogeux Christophe Ramière Caroline Charre Laurent Cotte Samuel Alizon Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
description	Opioid substitution and syringes exchange programs have drastically reduced hepatitis C virus (HCV) spread in France but HCV sexual transmission in men having sex with men (MSM) has recently arisen as a significant public health concern. The fact that the virus is transmitting in a heterogeneous population, with different transmission routes, makes prevalence and incidence rates poorly informative. However, additional insights can be gained by analyzing virus phylogenies inferred from dated genetic sequence data. By combining a phylodynamics approach based on Approximate Bayesian Computation (ABC) and an original transmission model, we estimate key epidemiological parameters of an ongoing HCV epidemic among MSMs in Lyon (France). We show that this new epidemic is largely independent of the previously observed non-MSM HCV epidemics and that its doubling time is ten times lower (0.44 years versus 4.37 years). These results have practical implications for HCV control and illustrate the additional information provided by virus genomics in public health.
format	article
author	Gonché Danesh Victor Virlogeux Christophe Ramière Caroline Charre Laurent Cotte Samuel Alizon
author_facet	Gonché Danesh Victor Virlogeux Christophe Ramière Caroline Charre Laurent Cotte Samuel Alizon
author_sort	Gonché Danesh
title	Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
title_short	Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
title_full	Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
title_fullStr	Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
title_full_unstemmed	Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.
title_sort	quantifying transmission dynamics of acute hepatitis c virus infections in a heterogeneous population using sequence data.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/168111c9bb4d4a738bd7ac2d3f43e650
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Quantifying transmission dynamics of acute hepatitis C virus infections in a heterogeneous population using sequence data.

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