Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus

Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulators of neuroinflammatory pathways in brain barrier ti...

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Autores principales:	Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C. D. Smyth, Emma Scotter, Miranda Aalderink, Sheryl Feng, Rebecca Johnson, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Maurice Curtis, Richard Faull, Mike Dragunow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
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spelling	oai:doaj.org-article:16813cdb8f5946e8a7e3b8526d12998c2021-12-02T13:34:31ZCardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus10.1038/s42003-021-01787-x2399-3642https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01787-xhttps://doaj.org/toc/2399-3642Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulators of neuroinflammatory pathways in brain barrier tissues such as vasculature, meninges and choroid plexus.Deidre JanssonVictor Birger DieriksJustin RustenhovenLeon C. D. SmythEmma ScotterMiranda AalderinkSheryl FengRebecca JohnsonPatrick SchwederEdward MeePeter HeppnerClinton TurnerMaurice CurtisRichard FaullMike DragunowNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Deidre Jansson Victor Birger Dieriks Justin Rustenhoven Leon C. D. Smyth Emma Scotter Miranda Aalderink Sheryl Feng Rebecca Johnson Patrick Schweder Edward Mee Peter Heppner Clinton Turner Maurice Curtis Richard Faull Mike Dragunow Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
description	Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulators of neuroinflammatory pathways in brain barrier tissues such as vasculature, meninges and choroid plexus.
format	article
author	Deidre Jansson Victor Birger Dieriks Justin Rustenhoven Leon C. D. Smyth Emma Scotter Miranda Aalderink Sheryl Feng Rebecca Johnson Patrick Schweder Edward Mee Peter Heppner Clinton Turner Maurice Curtis Richard Faull Mike Dragunow
author_facet	Deidre Jansson Victor Birger Dieriks Justin Rustenhoven Leon C. D. Smyth Emma Scotter Miranda Aalderink Sheryl Feng Rebecca Johnson Patrick Schweder Edward Mee Peter Heppner Clinton Turner Maurice Curtis Richard Faull Mike Dragunow
author_sort	Deidre Jansson
title	Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
title_short	Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
title_full	Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
title_fullStr	Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
title_full_unstemmed	Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
title_sort	cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
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Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus

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