Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice

Summary: Preterm birth may result in adverse health outcomes. Very preterm infants typically exhibit postnatal growth restriction, metabolic disturbances, and exaggerated inflammatory responses. We investigated the differences in the meconium microbiota composition between very preterm (<32 weeks...

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Autores principales:	Henni Hiltunen, Hila Hanani, Raakel Luoto, Sondra Turjeman, Oren Ziv, Erika Isolauri, Seppo Salminen, Omry Koren, Samuli Rautava
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	germ-free mice preterm infant gut microbiota fecal microbiota transplant growth inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1683e7a22fca4693b4f21ca6621f6cc1
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spelling	oai:doaj.org-article:1683e7a22fca4693b4f21ca6621f6cc12021-11-18T04:52:14ZPreterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice2666-379110.1016/j.xcrm.2021.100447https://doaj.org/article/1683e7a22fca4693b4f21ca6621f6cc12021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666379121003153https://doaj.org/toc/2666-3791Summary: Preterm birth may result in adverse health outcomes. Very preterm infants typically exhibit postnatal growth restriction, metabolic disturbances, and exaggerated inflammatory responses. We investigated the differences in the meconium microbiota composition between very preterm (<32 weeks), moderately preterm (32–37 weeks), and term (>37 weeks) human neonates by 16S rRNA gene sequencing. Human meconium microbiota transplants to germ-free mice were conducted to investigate whether the meconium microbiota is causally related to the preterm infant phenotype in an experimental model. Our results indicate that very preterm birth is associated with a distinct meconium microbiota composition. Fecal microbiota transplant of very preterm infant meconium results in impaired growth, altered intestinal immune function, and metabolic parameters as compared to term infant meconium transplants in germ-free mice. This finding suggests that measures aiming to minimize the long-term adverse consequences of very preterm birth should be commenced during pregnancy or directly after birth.Henni HiltunenHila HananiRaakel LuotoSondra TurjemanOren ZivErika IsolauriSeppo SalminenOmry KorenSamuli RautavaElsevierarticlegerm-free micepreterm infantgut microbiotafecal microbiota transplantgrowthinflammationMedicine (General)R5-920ENCell Reports Medicine, Vol 2, Iss 11, Pp 100447- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	germ-free mice preterm infant gut microbiota fecal microbiota transplant growth inflammation Medicine (General) R5-920
spellingShingle	germ-free mice preterm infant gut microbiota fecal microbiota transplant growth inflammation Medicine (General) R5-920 Henni Hiltunen Hila Hanani Raakel Luoto Sondra Turjeman Oren Ziv Erika Isolauri Seppo Salminen Omry Koren Samuli Rautava Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
description	Summary: Preterm birth may result in adverse health outcomes. Very preterm infants typically exhibit postnatal growth restriction, metabolic disturbances, and exaggerated inflammatory responses. We investigated the differences in the meconium microbiota composition between very preterm (<32 weeks), moderately preterm (32–37 weeks), and term (>37 weeks) human neonates by 16S rRNA gene sequencing. Human meconium microbiota transplants to germ-free mice were conducted to investigate whether the meconium microbiota is causally related to the preterm infant phenotype in an experimental model. Our results indicate that very preterm birth is associated with a distinct meconium microbiota composition. Fecal microbiota transplant of very preterm infant meconium results in impaired growth, altered intestinal immune function, and metabolic parameters as compared to term infant meconium transplants in germ-free mice. This finding suggests that measures aiming to minimize the long-term adverse consequences of very preterm birth should be commenced during pregnancy or directly after birth.
format	article
author	Henni Hiltunen Hila Hanani Raakel Luoto Sondra Turjeman Oren Ziv Erika Isolauri Seppo Salminen Omry Koren Samuli Rautava
author_facet	Henni Hiltunen Hila Hanani Raakel Luoto Sondra Turjeman Oren Ziv Erika Isolauri Seppo Salminen Omry Koren Samuli Rautava
author_sort	Henni Hiltunen
title	Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
title_short	Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
title_full	Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
title_fullStr	Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
title_full_unstemmed	Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
title_sort	preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1683e7a22fca4693b4f21ca6621f6cc1
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Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice

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