Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the pres...

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Autores principales:	Karen Zulema Meza-Valle, Rosa Alicia Saucedo-Acuña, Karla Lizzette Tovar-Carrillo, Juan Carlos Cuevas-González, Erasto Armando Zaragoza-Contreras, Juana Melgoza-Lozano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Aloe vera hydrogel support matrix skin regeneration wound healing Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/1686166ceda54091998436a9464d396d
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spelling	oai:doaj.org-article:1686166ceda54091998436a9464d396d2021-11-25T18:48:45ZCharacterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process10.3390/polym132239582073-4360https://doaj.org/article/1686166ceda54091998436a9464d396d2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3958https://doaj.org/toc/2073-4360Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.Karen Zulema Meza-ValleRosa Alicia Saucedo-AcuñaKarla Lizzette Tovar-CarrilloJuan Carlos Cuevas-GonzálezErasto Armando Zaragoza-ContrerasJuana Melgoza-LozanoMDPI AGarticleAloe verahydrogelsupport matrixskin regenerationwound healingOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3958, p 3958 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aloe vera hydrogel support matrix skin regeneration wound healing Organic chemistry QD241-441
spellingShingle	Aloe vera hydrogel support matrix skin regeneration wound healing Organic chemistry QD241-441 Karen Zulema Meza-Valle Rosa Alicia Saucedo-Acuña Karla Lizzette Tovar-Carrillo Juan Carlos Cuevas-González Erasto Armando Zaragoza-Contreras Juana Melgoza-Lozano Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
description	Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.
format	article
author	Karen Zulema Meza-Valle Rosa Alicia Saucedo-Acuña Karla Lizzette Tovar-Carrillo Juan Carlos Cuevas-González Erasto Armando Zaragoza-Contreras Juana Melgoza-Lozano
author_facet	Karen Zulema Meza-Valle Rosa Alicia Saucedo-Acuña Karla Lizzette Tovar-Carrillo Juan Carlos Cuevas-González Erasto Armando Zaragoza-Contreras Juana Melgoza-Lozano
author_sort	Karen Zulema Meza-Valle
title	Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
title_short	Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
title_full	Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
title_fullStr	Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
title_full_unstemmed	Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process
title_sort	characterization and topical study of aloe vera hydrogel on wound-healing process
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1686166ceda54091998436a9464d396d
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Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

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