A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period

Abstract Within the UK, child mortality from all causes has declined for all ages over the last three decades. However, distinct inequality remains, as child mortality rates are generally found to be higher in males. A significant proportion of childhood deaths in the UK occur in Paediatric Intensiv...

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Autores principales:	Ofran Almossawi, Scott O’Brien, Roger Parslow, Simon Nadel, Luigi Palla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/168d790aa4a84ef6ab06ea0a1b5a018c
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spelling	oai:doaj.org-article:168d790aa4a84ef6ab06ea0a1b5a018c2021-11-14T12:19:29ZA study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period10.1038/s41598-021-01173-x2045-2322https://doaj.org/article/168d790aa4a84ef6ab06ea0a1b5a018c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01173-xhttps://doaj.org/toc/2045-2322Abstract Within the UK, child mortality from all causes has declined for all ages over the last three decades. However, distinct inequality remains, as child mortality rates are generally found to be higher in males. A significant proportion of childhood deaths in the UK occur in Paediatric Intensive Care Units (PICU). We studied the association of sex with infant mortality in PICUs. We included all infants (0 to 12 months old) admitted to UK PICUs from 01/01/2005 to 31/12/2015 using the Paediatric Intensive Care Audit Network (PICANet) dataset. We considered first admissions to PICU and fitted a cause-specific-hazard-ratio (CSHR) model, and a logistic model to estimate the adjusted association between sex and mortality in PICU. Pre-defined subgroups were children less than 56-days old, and those with a primary diagnosis of infection. Of 71,243 cases, 1,411/29,520 (4.8%) of females, and 1,809/41,723 (4.3%) of males died. The adjusted male/female CSHR was 0.87 (95%-CI 0.81 to 0.92) representing a 13% higher risk of death for females. The adjusted OR for male to female mortality is 0.86 (95%-CI 0.80 to 0.93). Analyses in subgroups yielded similar findings. In our analysis, female infants have a higher rate of PICU mortality compared to male infants.Ofran AlmossawiScott O’BrienRoger ParslowSimon NadelLuigi PallaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ofran Almossawi Scott O’Brien Roger Parslow Simon Nadel Luigi Palla A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
description	Abstract Within the UK, child mortality from all causes has declined for all ages over the last three decades. However, distinct inequality remains, as child mortality rates are generally found to be higher in males. A significant proportion of childhood deaths in the UK occur in Paediatric Intensive Care Units (PICU). We studied the association of sex with infant mortality in PICUs. We included all infants (0 to 12 months old) admitted to UK PICUs from 01/01/2005 to 31/12/2015 using the Paediatric Intensive Care Audit Network (PICANet) dataset. We considered first admissions to PICU and fitted a cause-specific-hazard-ratio (CSHR) model, and a logistic model to estimate the adjusted association between sex and mortality in PICU. Pre-defined subgroups were children less than 56-days old, and those with a primary diagnosis of infection. Of 71,243 cases, 1,411/29,520 (4.8%) of females, and 1,809/41,723 (4.3%) of males died. The adjusted male/female CSHR was 0.87 (95%-CI 0.81 to 0.92) representing a 13% higher risk of death for females. The adjusted OR for male to female mortality is 0.86 (95%-CI 0.80 to 0.93). Analyses in subgroups yielded similar findings. In our analysis, female infants have a higher rate of PICU mortality compared to male infants.
format	article
author	Ofran Almossawi Scott O’Brien Roger Parslow Simon Nadel Luigi Palla
author_facet	Ofran Almossawi Scott O’Brien Roger Parslow Simon Nadel Luigi Palla
author_sort	Ofran Almossawi
title	A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
title_short	A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
title_full	A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
title_fullStr	A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
title_full_unstemmed	A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period
title_sort	study of sex difference in infant mortality in uk pediatric intensive care admissions over an 11-year period
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/168d790aa4a84ef6ab06ea0a1b5a018c
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A study of sex difference in infant mortality in UK pediatric intensive care admissions over an 11-year period

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