Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults

Objective: Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity (PWV) is a simple and noninvasive method for measuring arterial stiffnes...

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Autores principales:	Zhen-Zhen Zhang, Ping Wang, Xiang-Lei Kong, Wen-Li Mao, Mei-Yu Cui
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2019
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/168d9af3530943e693d75139f936bf77
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spelling	oai:doaj.org-article:168d9af3530943e693d75139f936bf772021-12-02T14:26:08ZAssociation of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults2095-882X10.1016/j.cdtm.2018.06.001https://doaj.org/article/168d9af3530943e693d75139f936bf772019-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300161https://doaj.org/toc/2095-882XObjective: Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity (PWV) is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations. Accordingly, we conducted a cross-sectional study to explore the association of Hb with PWV. Methods: A total of 6642 adults aged 54.5 ± 11.2 years undergoing physical examinations were enrolled, 71.7% of whom were males. Arterial stiffness was evaluated by carotid-femoral PWV (cfPWV). Multivariable regression analyses were performed to determine the relationship between Hb and increased cfPWV. Results: In this study, the mean Hb (per 10 g/L increase) was 144.7 ± 13.9 g/L, and the mean cfPWV was 15.1 ± 3.1 m/s. cfPWV was significantly higher in high hemoglobin groups ≥15.4 g/L (Quartile 4) than in the lowest hemoglobin group (Quartile 1 ≤ 13.6 g/L; P < 0.001). Multiple linear regression analysis revealed that Hb positively correlated with cfPWV (β = 0.16, P < 0.01). Univariate Logistic regression analysis revealed that Hb was associated with increased cfPWV, with an odd ratio (OR) of 1.46 (95% confidence interval [CI], 1.39–1.54). After adjusting for potential confounders, Hb and the highest Hb quartile group were also independently associated with increased cfPWV, with a fully adjusted OR of 1.11 (95% CI, 1.02–1.20) and 1.45 (95% CI, 1.01–2.08), respectively. Conclusion: This study demonstrated that Hb levels significantly correlate with increased cfPWV. Keywords: Hemoglobin, Pulse wave velocity, Arterial stiffness, Cardiovascular diseasesZhen-Zhen ZhangPing WangXiang-Lei KongWen-Li MaoMei-Yu CuiKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 2, Pp 122-128 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhen-Zhen Zhang Ping Wang Xiang-Lei Kong Wen-Li Mao Mei-Yu Cui Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
description	Objective: Increased hemoglobin (Hb) levels are known to be associated with increased cardiovascular events and mortalities. Therefore, we assumed that high Hb levels were associated with arterial stiffness. Pulse wave velocity (PWV) is a simple and noninvasive method for measuring arterial stiffness to assess cardiovascular disease in general populations. Accordingly, we conducted a cross-sectional study to explore the association of Hb with PWV. Methods: A total of 6642 adults aged 54.5 ± 11.2 years undergoing physical examinations were enrolled, 71.7% of whom were males. Arterial stiffness was evaluated by carotid-femoral PWV (cfPWV). Multivariable regression analyses were performed to determine the relationship between Hb and increased cfPWV. Results: In this study, the mean Hb (per 10 g/L increase) was 144.7 ± 13.9 g/L, and the mean cfPWV was 15.1 ± 3.1 m/s. cfPWV was significantly higher in high hemoglobin groups ≥15.4 g/L (Quartile 4) than in the lowest hemoglobin group (Quartile 1 ≤ 13.6 g/L; P < 0.001). Multiple linear regression analysis revealed that Hb positively correlated with cfPWV (β = 0.16, P < 0.01). Univariate Logistic regression analysis revealed that Hb was associated with increased cfPWV, with an odd ratio (OR) of 1.46 (95% confidence interval [CI], 1.39–1.54). After adjusting for potential confounders, Hb and the highest Hb quartile group were also independently associated with increased cfPWV, with a fully adjusted OR of 1.11 (95% CI, 1.02–1.20) and 1.45 (95% CI, 1.01–2.08), respectively. Conclusion: This study demonstrated that Hb levels significantly correlate with increased cfPWV. Keywords: Hemoglobin, Pulse wave velocity, Arterial stiffness, Cardiovascular diseases
format	article
author	Zhen-Zhen Zhang Ping Wang Xiang-Lei Kong Wen-Li Mao Mei-Yu Cui
author_facet	Zhen-Zhen Zhang Ping Wang Xiang-Lei Kong Wen-Li Mao Mei-Yu Cui
author_sort	Zhen-Zhen Zhang
title	Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
title_short	Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
title_full	Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
title_fullStr	Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
title_full_unstemmed	Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults
title_sort	association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among chinese adults
publisher	KeAi Communications Co., Ltd.
publishDate	2019
url	https://doaj.org/article/168d9af3530943e693d75139f936bf77
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Association of hemoglobin with arterial stiffness evaluated by carotid-femoral pulse wave velocity among Chinese adults

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