Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study

Abstract Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stroma...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Shu Wei Ting, Yasuo Yanagi, Rupesh Agrawal, Hwei Yee Teo, Sophia Seen, Ian Yew San Yeo, Ranjana Mathur, Choi Mun Chan, Shu Yen Lee, Edmund Yick Mun Wong, Doric Wong, Tien Yin Wong, Gemmy Chui Ming Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/168e812a36df43ab8f54e5b2777cd2c2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:168e812a36df43ab8f54e5b2777cd2c2
record_format	dspace
spelling	oai:doaj.org-article:168e812a36df43ab8f54e5b2777cd2c22021-12-02T11:52:41ZChoroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study10.1038/s41598-017-08276-42045-2322https://doaj.org/article/168e812a36df43ab8f54e5b2777cd2c22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08276-4https://doaj.org/toc/2045-2322Abstract Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area). At baseline, PCV eyes had higher CRT (471.6 µm vs 439.1 µm, p = 0.02), but comparable subfoveal CT and CVI, compared to t-AMD. Eyes with high CVI at baseline showed marked reduction in stromal area compared with eyes with average or low CVI. Over 12 months, CRT and subfoveal CT significantly decreased (p < 0.001) in both subtypes. Eyes with high baseline CVI showed significant CVI reduction from baseline to month 12 (p < 0.001), whereas eyes with average to low baseline CVI showed increase in CVI. These differences in choroidal vascularity may reflect different predominant pathogenic processes and remodeling in AMD eyes with varying spectrum.Daniel Shu Wei TingYasuo YanagiRupesh AgrawalHwei Yee TeoSophia SeenIan Yew San YeoRanjana MathurChoi Mun ChanShu Yen LeeEdmund Yick Mun WongDoric WongTien Yin WongGemmy Chui Ming CheungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Shu Wei Ting Yasuo Yanagi Rupesh Agrawal Hwei Yee Teo Sophia Seen Ian Yew San Yeo Ranjana Mathur Choi Mun Chan Shu Yen Lee Edmund Yick Mun Wong Doric Wong Tien Yin Wong Gemmy Chui Ming Cheung Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
description	Abstract Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area). At baseline, PCV eyes had higher CRT (471.6 µm vs 439.1 µm, p = 0.02), but comparable subfoveal CT and CVI, compared to t-AMD. Eyes with high CVI at baseline showed marked reduction in stromal area compared with eyes with average or low CVI. Over 12 months, CRT and subfoveal CT significantly decreased (p < 0.001) in both subtypes. Eyes with high baseline CVI showed significant CVI reduction from baseline to month 12 (p < 0.001), whereas eyes with average to low baseline CVI showed increase in CVI. These differences in choroidal vascularity may reflect different predominant pathogenic processes and remodeling in AMD eyes with varying spectrum.
format	article
author	Daniel Shu Wei Ting Yasuo Yanagi Rupesh Agrawal Hwei Yee Teo Sophia Seen Ian Yew San Yeo Ranjana Mathur Choi Mun Chan Shu Yen Lee Edmund Yick Mun Wong Doric Wong Tien Yin Wong Gemmy Chui Ming Cheung
author_facet	Daniel Shu Wei Ting Yasuo Yanagi Rupesh Agrawal Hwei Yee Teo Sophia Seen Ian Yew San Yeo Ranjana Mathur Choi Mun Chan Shu Yen Lee Edmund Yick Mun Wong Doric Wong Tien Yin Wong Gemmy Chui Ming Cheung
author_sort	Daniel Shu Wei Ting
title	Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
title_short	Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
title_full	Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
title_fullStr	Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
title_full_unstemmed	Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study
title_sort	choroidal remodeling in age-related macular degeneration and polypoidal choroidal vasculopathy: a 12-month prospective study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/168e812a36df43ab8f54e5b2777cd2c2
work_keys_str_mv	AT danielshuweiting choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT yasuoyanagi choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT rupeshagrawal choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT hweiyeeteo choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT sophiaseen choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT ianyewsanyeo choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT ranjanamathur choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT choimunchan choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT shuyenlee choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT edmundyickmunwong choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT doricwong choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT tienyinwong choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy AT gemmychuimingcheung choroidalremodelinginagerelatedmaculardegenerationandpolypoidalchoroidalvasculopathya12monthprospectivestudy
_version_	1718394967796219904

Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study

Ejemplares similares