Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model

Killing bacteria, eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment. In order to endow Ti implants with above abilities, multifunctional coatings consisted of Fe2O3–FeOOH nanograins as an outer layer and Z...

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Autores principales:	Yang Xue, Jun Chen, Tiexin Ding, Mengting Mao, Shengbo Zhu, Jianhong Zhou, Lan Zhang, Yong Han
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Photothermal Fe2O3–FeOOH Antibacterial Biointegration Soft tissue Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/168f29f30d334cc0bf5df0b783765fb1
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id	oai:doaj.org-article:168f29f30d334cc0bf5df0b783765fb1
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spelling	oai:doaj.org-article:168f29f30d334cc0bf5df0b783765fb12021-11-04T04:36:03ZBuilding biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model2452-199X10.1016/j.bioactmat.2021.06.029https://doaj.org/article/168f29f30d334cc0bf5df0b783765fb12022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003157https://doaj.org/toc/2452-199XKilling bacteria, eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment. In order to endow Ti implants with above abilities, multifunctional coatings consisted of Fe2O3–FeOOH nanograins as an outer layer and Zn doped microporous TiO2 as an inner layer were fabricated by micro-arc oxidation, hydrothermal treatment and annealing treatment. The microstructures, physicochemical properties and photothermal response of the coatings were observed; their antibacterial efficiencies and cell response in vitro as well as biofilm elimination and soft tissue integration in vivo were evaluated. The results show that with the increased annealing temperature, coating morphologies didn't change obviously, but lattices of β-FeOOH gradually disorganized into amorphous state and rearranged to form Fe2O3. The coating annealed at 450 °C (MA450) had nanocrystallized Fe2O3 and β-FeOOH. With a proper NIR irradiation strategy, MA450 killed adhered bacteria efficiently and increased fibroblast behaviors via up-regulating fibrogenic-related genes in vitro; in an infected model, MA450 eliminated biofilm, reduced inflammatory response and improved biointegration with soft tissue. The good performance of MA450 was due to a synergic effect of photothermal response and released ions (Zn2+ and Fe3+).Yang XueJun ChenTiexin DingMengting MaoShengbo ZhuJianhong ZhouLan ZhangYong HanKeAi Communications Co., Ltd.articlePhotothermalFe2O3–FeOOHAntibacterialBiointegrationSoft tissueMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 1-11 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Photothermal Fe2O3–FeOOH Antibacterial Biointegration Soft tissue Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Photothermal Fe2O3–FeOOH Antibacterial Biointegration Soft tissue Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Yang Xue Jun Chen Tiexin Ding Mengting Mao Shengbo Zhu Jianhong Zhou Lan Zhang Yong Han Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
description	Killing bacteria, eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment. In order to endow Ti implants with above abilities, multifunctional coatings consisted of Fe2O3–FeOOH nanograins as an outer layer and Zn doped microporous TiO2 as an inner layer were fabricated by micro-arc oxidation, hydrothermal treatment and annealing treatment. The microstructures, physicochemical properties and photothermal response of the coatings were observed; their antibacterial efficiencies and cell response in vitro as well as biofilm elimination and soft tissue integration in vivo were evaluated. The results show that with the increased annealing temperature, coating morphologies didn't change obviously, but lattices of β-FeOOH gradually disorganized into amorphous state and rearranged to form Fe2O3. The coating annealed at 450 °C (MA450) had nanocrystallized Fe2O3 and β-FeOOH. With a proper NIR irradiation strategy, MA450 killed adhered bacteria efficiently and increased fibroblast behaviors via up-regulating fibrogenic-related genes in vitro; in an infected model, MA450 eliminated biofilm, reduced inflammatory response and improved biointegration with soft tissue. The good performance of MA450 was due to a synergic effect of photothermal response and released ions (Zn2+ and Fe3+).
format	article
author	Yang Xue Jun Chen Tiexin Ding Mengting Mao Shengbo Zhu Jianhong Zhou Lan Zhang Yong Han
author_facet	Yang Xue Jun Chen Tiexin Ding Mengting Mao Shengbo Zhu Jianhong Zhou Lan Zhang Yong Han
author_sort	Yang Xue
title	Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
title_short	Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
title_full	Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
title_fullStr	Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
title_full_unstemmed	Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model
title_sort	building biointegration of fe2o3–feooh coated titanium implant by regulating nir irradiation in an infected model
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/168f29f30d334cc0bf5df0b783765fb1
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Building biointegration of Fe2O3–FeOOH coated titanium implant by regulating NIR irradiation in an infected model

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