Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.

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Autores principales:	Nicholas F. Fitz, Kyong Nyon Nam, Cody M. Wolfe, Florent Letronne, Brittany E. Playso, Bistra E. Iordanova, Takashi D. Y. Kozai, Richard J. Biedrzycki, Valerian E. Kagan, Yulia Y. Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc
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spelling	oai:doaj.org-article:16908adbabbe48e7b4e51149f560d6dc2021-12-02T14:58:23ZPhospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease10.1038/s41467-021-23762-02041-1723https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23762-0https://doaj.org/toc/2041-1723Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.Nicholas F. FitzKyong Nyon NamCody M. WolfeFlorent LetronneBrittany E. PlaysoBistra E. IordanovaTakashi D. Y. KozaiRichard J. BiedrzyckiValerian E. KaganYulia Y. TyurinaXianlin HanIliya LefterovRadosveta KoldamovaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas F. Fitz Kyong Nyon Nam Cody M. Wolfe Florent Letronne Brittany E. Playso Bistra E. Iordanova Takashi D. Y. Kozai Richard J. Biedrzycki Valerian E. Kagan Yulia Y. Tyurina Xianlin Han Iliya Lefterov Radosveta Koldamova Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
description	Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.
format	article
author	Nicholas F. Fitz Kyong Nyon Nam Cody M. Wolfe Florent Letronne Brittany E. Playso Bistra E. Iordanova Takashi D. Y. Kozai Richard J. Biedrzycki Valerian E. Kagan Yulia Y. Tyurina Xianlin Han Iliya Lefterov Radosveta Koldamova
author_facet	Nicholas F. Fitz Kyong Nyon Nam Cody M. Wolfe Florent Letronne Brittany E. Playso Bistra E. Iordanova Takashi D. Y. Kozai Richard J. Biedrzycki Valerian E. Kagan Yulia Y. Tyurina Xianlin Han Iliya Lefterov Radosveta Koldamova
author_sort	Nicholas F. Fitz
title	Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
title_short	Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
title_full	Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
title_fullStr	Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
title_full_unstemmed	Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
title_sort	phospholipids of apoe lipoproteins activate microglia in an isoform-specific manner in preclinical models of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc
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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

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