Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration

Abstract Management of diabetes-related foot ulceration (DFU) includes pressure offloading resulting in a period of reduced activity. The metabolic effects of this are unknown. This study aims to investigate changes in bone mineral density (BMD) and body composition 12 weeks after hospitalisation fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marcel M. Nejatian, Salar Sobhi, Blake N. Sanchez, Kathryn Linn, Laurens Manning, Shuen-Chyn Soh, Jonathan Hiew, J. Carsten Ritter, Bu B. Yeap, Emma J. Hamilton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16928dbe6bf543a09e06a05c0097261b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16928dbe6bf543a09e06a05c0097261b
record_format	dspace
spelling	oai:doaj.org-article:16928dbe6bf543a09e06a05c0097261b2021-11-28T12:15:57ZReduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration10.1038/s41598-021-02233-y2045-2322https://doaj.org/article/16928dbe6bf543a09e06a05c0097261b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02233-yhttps://doaj.org/toc/2045-2322Abstract Management of diabetes-related foot ulceration (DFU) includes pressure offloading resulting in a period of reduced activity. The metabolic effects of this are unknown. This study aims to investigate changes in bone mineral density (BMD) and body composition 12 weeks after hospitalisation for DFU. A longitudinal, prospective, observational study of 22 people hospitalised for DFU was conducted. Total body, lumbar spine, hip and forearm BMD, and total lean and fat mass were measured by dual-energy X-ray absorptiometry (DXA) during and 12 weeks after hospitalisation for DFU. Significant losses in total hip BMD of the ipsilateral limb (− 1.7%, p < 0.001), total hip BMD of the contralateral limb (− 1.4%, p = 0.005), femoral neck BMD of the ipsilateral limb (− 2.8%, p < 0.001) and femoral neck BMD of the contralateral limb (− 2.2%, p = 0.008) were observed after 12 weeks. Lumbar spine and forearm BMD were unchanged. HbA1c improved from 75 mmol/mol (9.2%) to 64 mmol/mol (8.0%) (p = 0.002). No significant changes to lean and fat mass were demonstrated. Total hip and femoral neck BMD decreased bilaterally 12 weeks after hospitalisation for DFU. Future research is required to confirm the persistence and clinical implications of these losses.Marcel M. NejatianSalar SobhiBlake N. SanchezKathryn LinnLaurens ManningShuen-Chyn SohJonathan HiewJ. Carsten RitterBu B. YeapEmma J. HamiltonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcel M. Nejatian Salar Sobhi Blake N. Sanchez Kathryn Linn Laurens Manning Shuen-Chyn Soh Jonathan Hiew J. Carsten Ritter Bu B. Yeap Emma J. Hamilton Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
description	Abstract Management of diabetes-related foot ulceration (DFU) includes pressure offloading resulting in a period of reduced activity. The metabolic effects of this are unknown. This study aims to investigate changes in bone mineral density (BMD) and body composition 12 weeks after hospitalisation for DFU. A longitudinal, prospective, observational study of 22 people hospitalised for DFU was conducted. Total body, lumbar spine, hip and forearm BMD, and total lean and fat mass were measured by dual-energy X-ray absorptiometry (DXA) during and 12 weeks after hospitalisation for DFU. Significant losses in total hip BMD of the ipsilateral limb (− 1.7%, p < 0.001), total hip BMD of the contralateral limb (− 1.4%, p = 0.005), femoral neck BMD of the ipsilateral limb (− 2.8%, p < 0.001) and femoral neck BMD of the contralateral limb (− 2.2%, p = 0.008) were observed after 12 weeks. Lumbar spine and forearm BMD were unchanged. HbA1c improved from 75 mmol/mol (9.2%) to 64 mmol/mol (8.0%) (p = 0.002). No significant changes to lean and fat mass were demonstrated. Total hip and femoral neck BMD decreased bilaterally 12 weeks after hospitalisation for DFU. Future research is required to confirm the persistence and clinical implications of these losses.
format	article
author	Marcel M. Nejatian Salar Sobhi Blake N. Sanchez Kathryn Linn Laurens Manning Shuen-Chyn Soh Jonathan Hiew J. Carsten Ritter Bu B. Yeap Emma J. Hamilton
author_facet	Marcel M. Nejatian Salar Sobhi Blake N. Sanchez Kathryn Linn Laurens Manning Shuen-Chyn Soh Jonathan Hiew J. Carsten Ritter Bu B. Yeap Emma J. Hamilton
author_sort	Marcel M. Nejatian
title	Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
title_short	Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
title_full	Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
title_fullStr	Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
title_full_unstemmed	Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
title_sort	reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16928dbe6bf543a09e06a05c0097261b
work_keys_str_mv	AT marcelmnejatian reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT salarsobhi reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT blakensanchez reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT kathrynlinn reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT laurensmanning reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT shuenchynsoh reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT jonathanhiew reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT jcarstenritter reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT bubyeap reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration AT emmajhamilton reductioninfemoralneckandtotalhipbonemineraldensityfollowinghospitalisationfordiabetesrelatedfootulceration
_version_	1718408061160259584

Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration

Ejemplares similares