Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma

Abstract The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi Liu, Hua Liu, Chang-Lin Qian, Mei-Sui Lin, Feng-Hua Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16965573aa66437ba66878eaa5d8985b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16965573aa66437ba66878eaa5d8985b
record_format	dspace
spelling	oai:doaj.org-article:16965573aa66437ba66878eaa5d8985b2021-12-02T16:08:22ZUtility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma10.1038/s41598-017-01650-22045-2322https://doaj.org/article/16965573aa66437ba66878eaa5d8985b2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01650-2https://doaj.org/toc/2045-2322Abstract The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The diagnostic efficacy of quantitative CEUS and tumor size was analyzed. The qualitative CEUS features did not differ significantly between the ECE and non-ECE groups (P > 0.05). All of the quantitative CEUS parameters with the exception of peak intensity and tumor size were found to differ significantly between the ECE and non-ECE groups (P < 0.05). Multivariate stepwise logistic regression analysis demonstrated that time from peak to one half (TPH), tumor size and wash-in slope (WIS) were the significantly different parameters between the ECE and non-ECE groups (P = 0.000, P = 0.005 and P = 0.030, respectively).The sensitivity and specificity in the diagnosis of ECE were: TPH, 75.4% (43/57) and 78.9% (41/52), respectively; WIS, 87.7% (50/57) and 42.3% (22/52), respectively; and tumor size, 71.9% (41/57) and 65.4% (34/52), respectively. Quantitative CEUS analysis and tumor size are essential for the prediction of ECE in PTC; in particular TPH has good diagnostic value in detecting ECE. Our study provides important insights into the prediction of ECE in PTC.Yi LiuHua LiuChang-Lin QianMei-Sui LinFeng-Hua LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Liu Hua Liu Chang-Lin Qian Mei-Sui Lin Feng-Hua Li Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
description	Abstract The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The diagnostic efficacy of quantitative CEUS and tumor size was analyzed. The qualitative CEUS features did not differ significantly between the ECE and non-ECE groups (P > 0.05). All of the quantitative CEUS parameters with the exception of peak intensity and tumor size were found to differ significantly between the ECE and non-ECE groups (P < 0.05). Multivariate stepwise logistic regression analysis demonstrated that time from peak to one half (TPH), tumor size and wash-in slope (WIS) were the significantly different parameters between the ECE and non-ECE groups (P = 0.000, P = 0.005 and P = 0.030, respectively).The sensitivity and specificity in the diagnosis of ECE were: TPH, 75.4% (43/57) and 78.9% (41/52), respectively; WIS, 87.7% (50/57) and 42.3% (22/52), respectively; and tumor size, 71.9% (41/57) and 65.4% (34/52), respectively. Quantitative CEUS analysis and tumor size are essential for the prediction of ECE in PTC; in particular TPH has good diagnostic value in detecting ECE. Our study provides important insights into the prediction of ECE in PTC.
format	article
author	Yi Liu Hua Liu Chang-Lin Qian Mei-Sui Lin Feng-Hua Li
author_facet	Yi Liu Hua Liu Chang-Lin Qian Mei-Sui Lin Feng-Hua Li
author_sort	Yi Liu
title	Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
title_short	Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
title_full	Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
title_fullStr	Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
title_full_unstemmed	Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
title_sort	utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/16965573aa66437ba66878eaa5d8985b
work_keys_str_mv	AT yiliu utilityofquantitativecontrastenhancedultrasoundforthepredictionofextracapsularextensioninpapillarythyroidcarcinoma AT hualiu utilityofquantitativecontrastenhancedultrasoundforthepredictionofextracapsularextensioninpapillarythyroidcarcinoma AT changlinqian utilityofquantitativecontrastenhancedultrasoundforthepredictionofextracapsularextensioninpapillarythyroidcarcinoma AT meisuilin utilityofquantitativecontrastenhancedultrasoundforthepredictionofextracapsularextensioninpapillarythyroidcarcinoma AT fenghuali utilityofquantitativecontrastenhancedultrasoundforthepredictionofextracapsularextensioninpapillarythyroidcarcinoma
_version_	1718384515643080704

Utility of quantitative contrast-enhanced ultrasound for the prediction of extracapsular extension in papillary thyroid carcinoma

Ejemplares similares