Malignant Neoplasms of the Anal Canal

Background Malignant neoplasms of the anal canal are rare, accounting for approximately 4% of all colorectal malignancies. Objectives The present study aimed to report the clinicopathological characteristics and treatment outcomes of 41 cases with malignant neoplasms of the anal canal. Patie...

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Autores principales:	Shapour Omidvari, Sayed Hasan, Samira Razzaghi, Hamid Nasrolahi, Ahmad Mosalaei, Niloofar Ahmadloo, Mansour Ansari
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2013
Materias:	malignant neoplasms anal canal carcinoma squamous cell adenocarcinoma melanoma gastrointestinal stromal tumor Medicine R
Acceso en línea:	https://doaj.org/article/169858a7852d4f90b06cb85c2945dc19
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spelling	oai:doaj.org-article:169858a7852d4f90b06cb85c2945dc192021-11-14T07:53:33ZMalignant Neoplasms of the Anal Canal2783-243010.17795/acr-11985https://doaj.org/article/169858a7852d4f90b06cb85c2945dc192013-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45447_742bdc77d883a29bf47c962fb0712c3e.pdfhttps://doaj.org/toc/2783-2430Background Malignant neoplasms of the anal canal are rare, accounting for approximately 4% of all colorectal malignancies. Objectives The present study aimed to report the clinicopathological characteristics and treatment outcomes of 41 cases with malignant neoplasms of the anal canal. Patients and Methods Between 1999 and 2012, 41 consecutive patients were diagnosed with primary malignant neoplasm of the anal canal, who were treated and followed up at Namazi hospital. Only primary malignant tumors arising from the anal canal were included. Patients with secondary anal canal involvement from rectal or perianal skin cancers and metastatic tumors were excluded. Results There were 22 women and 19 men, aged 33 to 83 years, with a median age of 57 years at diagnosis. Sixteen patients (39%) had localized disease, 21 (51%) had regional disease, and 4 (10%) had metastatic disease at diagnosis. Squamous cell carcinoma (61%) was the most frequent histologic subtype, followed by adenocarcinoma (27%), malignant melanoma (10%), and gastrointestinal stromal tumor (2%). After a median follow-up of 51 (11-169) months for surviving patients, 22 patients were alive and without disease, three were alive with disease, and 19 patients died due to the disease. Histological subtype (P = 001), and stage of disease (P = 0.002) were prognostic factors for overall survival. The 5-year local control, disease-free, and overall survival rates for all patients were 63.9%, 53%, and 59.4% respectively. Conclusions This study indicated that squamous cell carcinoma, adenocarcinoma, and malignant melanoma are the most frequent malignant neoplasms in the anal canal. Histological subtype and disease stage are the most important prognostic factors for overall survival in this region.Shapour OmidvariSayed HasanSamira RazzaghiHamid NasrolahiAhmad MosalaeiNiloofar AhmadlooMansour AnsariShiraz University of Medical Sciencesarticlemalignant neoplasmsanal canal carcinoma squamous celladenocarcinomamelanomagastrointestinal stromal tumorMedicineRENIranian Journal of Colorectal Research, Vol 1, Iss 2, Pp 4-5 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant neoplasms anal canal carcinoma squamous cell adenocarcinoma melanoma gastrointestinal stromal tumor Medicine R
spellingShingle	malignant neoplasms anal canal carcinoma squamous cell adenocarcinoma melanoma gastrointestinal stromal tumor Medicine R Shapour Omidvari Sayed Hasan Samira Razzaghi Hamid Nasrolahi Ahmad Mosalaei Niloofar Ahmadloo Mansour Ansari Malignant Neoplasms of the Anal Canal
description	Background Malignant neoplasms of the anal canal are rare, accounting for approximately 4% of all colorectal malignancies. Objectives The present study aimed to report the clinicopathological characteristics and treatment outcomes of 41 cases with malignant neoplasms of the anal canal. Patients and Methods Between 1999 and 2012, 41 consecutive patients were diagnosed with primary malignant neoplasm of the anal canal, who were treated and followed up at Namazi hospital. Only primary malignant tumors arising from the anal canal were included. Patients with secondary anal canal involvement from rectal or perianal skin cancers and metastatic tumors were excluded. Results There were 22 women and 19 men, aged 33 to 83 years, with a median age of 57 years at diagnosis. Sixteen patients (39%) had localized disease, 21 (51%) had regional disease, and 4 (10%) had metastatic disease at diagnosis. Squamous cell carcinoma (61%) was the most frequent histologic subtype, followed by adenocarcinoma (27%), malignant melanoma (10%), and gastrointestinal stromal tumor (2%). After a median follow-up of 51 (11-169) months for surviving patients, 22 patients were alive and without disease, three were alive with disease, and 19 patients died due to the disease. Histological subtype (P = 001), and stage of disease (P = 0.002) were prognostic factors for overall survival. The 5-year local control, disease-free, and overall survival rates for all patients were 63.9%, 53%, and 59.4% respectively. Conclusions This study indicated that squamous cell carcinoma, adenocarcinoma, and malignant melanoma are the most frequent malignant neoplasms in the anal canal. Histological subtype and disease stage are the most important prognostic factors for overall survival in this region.
format	article
author	Shapour Omidvari Sayed Hasan Samira Razzaghi Hamid Nasrolahi Ahmad Mosalaei Niloofar Ahmadloo Mansour Ansari
author_facet	Shapour Omidvari Sayed Hasan Samira Razzaghi Hamid Nasrolahi Ahmad Mosalaei Niloofar Ahmadloo Mansour Ansari
author_sort	Shapour Omidvari
title	Malignant Neoplasms of the Anal Canal
title_short	Malignant Neoplasms of the Anal Canal
title_full	Malignant Neoplasms of the Anal Canal
title_fullStr	Malignant Neoplasms of the Anal Canal
title_full_unstemmed	Malignant Neoplasms of the Anal Canal
title_sort	malignant neoplasms of the anal canal
publisher	Shiraz University of Medical Sciences
publishDate	2013
url	https://doaj.org/article/169858a7852d4f90b06cb85c2945dc19
work_keys_str_mv	AT shapouromidvari malignantneoplasmsoftheanalcanal AT sayedhasan malignantneoplasmsoftheanalcanal AT samirarazzaghi malignantneoplasmsoftheanalcanal AT hamidnasrolahi malignantneoplasmsoftheanalcanal AT ahmadmosalaei malignantneoplasmsoftheanalcanal AT niloofarahmadloo malignantneoplasmsoftheanalcanal AT mansouransari malignantneoplasmsoftheanalcanal
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Malignant Neoplasms of the Anal Canal

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