Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin

The organisms possess antioxidant defense systems, including antioxidant enzymessuch as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase(CAT), to deal with the reactive oxygen species generated in physiological andpathophysiological situations. Melatonin was recently shown to...

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Autores principales:	Mükerrem Betül Yerer, Sami Aydoğan, Recep Saraymen
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2006
Materias:	Sepsis Melatonin Glutathione Peroxidase (GSH-Px) Superoxide Dismutase (SOD) Catalase (CAT) Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/1699e7f41c01463b8867a727cfcc3895
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spelling	oai:doaj.org-article:1699e7f41c01463b8867a727cfcc38952021-12-02T12:33:26ZAlterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin0250-46851303-829Xhttps://doaj.org/article/1699e7f41c01463b8867a727cfcc38952006-09-01T00:00:00Zhttp://www.turkjbiochem.com/2006/106.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XThe organisms possess antioxidant defense systems, including antioxidant enzymessuch as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase(CAT), to deal with the reactive oxygen species generated in physiological andpathophysiological situations. Melatonin was recently shown to act as a putativeantioxidant in the pathology of many diseases. The aim of this study was to investigatethe effects of melatonin on antioxidant enzyme activities in septic rats. Swiss albinomale rats weighing 250-300 g were randomly divided into 4 groups comprising of10 animals in each group. The first group was the control group. The second groupwas given melatonin (10 mg/kg) and third group was given only lipopolysaccharide(LPS, 10 mg/kg) by i.p. injection. The fourth group received melatonin (10 mg/kg,i.p.) after 4 hours than the LPS administration. All the rats in 4 groups were killedat the end of the 6th hour after the first injection. The erythrocytes isolated fromthe whole blood were used to evaluate the GSH-Px, SOD and CAT activities. Asa result, GSH-Px, SOD were significantly stimulated in sepsis with LPS treatmentwhere CAT activities were decreased. Furthermore, GSH-Px and SOD activitieswere triggered significantly by melatonin administration, whereas the CAT activityreduced. These findings reveal that melatonin stimulates the antioxidant enzymeactivities in the erythrocytes of septic rats, but further information is required tofind out its inhibitory effects on the CAT activity.Mükerrem Betül YererSami AydoğanRecep SaraymenDe GruyterarticleSepsisMelatoninGlutathione Peroxidase (GSH-Px)Superoxide Dismutase (SOD)Catalase (CAT)BiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 31, Iss 3, Pp 124-128 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sepsis Melatonin Glutathione Peroxidase (GSH-Px) Superoxide Dismutase (SOD) Catalase (CAT) Biochemistry QD415-436
spellingShingle	Sepsis Melatonin Glutathione Peroxidase (GSH-Px) Superoxide Dismutase (SOD) Catalase (CAT) Biochemistry QD415-436 Mükerrem Betül Yerer Sami Aydoğan Recep Saraymen Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
description	The organisms possess antioxidant defense systems, including antioxidant enzymessuch as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase(CAT), to deal with the reactive oxygen species generated in physiological andpathophysiological situations. Melatonin was recently shown to act as a putativeantioxidant in the pathology of many diseases. The aim of this study was to investigatethe effects of melatonin on antioxidant enzyme activities in septic rats. Swiss albinomale rats weighing 250-300 g were randomly divided into 4 groups comprising of10 animals in each group. The first group was the control group. The second groupwas given melatonin (10 mg/kg) and third group was given only lipopolysaccharide(LPS, 10 mg/kg) by i.p. injection. The fourth group received melatonin (10 mg/kg,i.p.) after 4 hours than the LPS administration. All the rats in 4 groups were killedat the end of the 6th hour after the first injection. The erythrocytes isolated fromthe whole blood were used to evaluate the GSH-Px, SOD and CAT activities. Asa result, GSH-Px, SOD were significantly stimulated in sepsis with LPS treatmentwhere CAT activities were decreased. Furthermore, GSH-Px and SOD activitieswere triggered significantly by melatonin administration, whereas the CAT activityreduced. These findings reveal that melatonin stimulates the antioxidant enzymeactivities in the erythrocytes of septic rats, but further information is required tofind out its inhibitory effects on the CAT activity.
format	article
author	Mükerrem Betül Yerer Sami Aydoğan Recep Saraymen
author_facet	Mükerrem Betül Yerer Sami Aydoğan Recep Saraymen
author_sort	Mükerrem Betül Yerer
title	Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
title_short	Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
title_full	Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
title_fullStr	Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
title_full_unstemmed	Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin
title_sort	alterations in the erythrocyte antioxidant enzyme levels in experimental sepsis: role of melatonin
publisher	De Gruyter
publishDate	2006
url	https://doaj.org/article/1699e7f41c01463b8867a727cfcc3895
work_keys_str_mv	AT mukerrembetulyerer alterationsintheerythrocyteantioxidantenzymelevelsinexperimentalsepsisroleofmelatonin AT samiaydogan alterationsintheerythrocyteantioxidantenzymelevelsinexperimentalsepsisroleofmelatonin AT recepsaraymen alterationsintheerythrocyteantioxidantenzymelevelsinexperimentalsepsisroleofmelatonin
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Alterations in the Erythrocyte Antioxidant Enzyme Levels in Experimental Sepsis: Role of Melatonin

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