Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus

Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology an...

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Autores principales:	Tafere GG, Wondafrash DZ, Zewdie KA, Assefa BT, Ayza MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adipsin type2 diabetes mellitus biomarker Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/169c311a190547a9b9cc3b5da5b28bda
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spelling	oai:doaj.org-article:169c311a190547a9b9cc3b5da5b28bda2021-12-02T08:18:13ZPlasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/169c311a190547a9b9cc3b5da5b28bda2020-05-01T00:00:00Zhttps://www.dovepress.com/plasma-adipsin-as-a-biomarker-and-its-implication-in-type-2-diabetes-m-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology and Toxicology,School of Pharmacy, Mekelle University, P.O. Box: 1871, Mekelle, EthiopiaTel +251 908822323Email gebrehiwotg07@gmail.comAbstract: Diabetes mellitus (DM) is a worldwide health threat affecting millions of people, which is associated with different micro- and macro-vascular complications. Type 2 diabetes mellitus (T2DM) is one of the different types of DM caused by insulin resistance and/or reduced secretion of insulin from the pancreas. A validated novel biomarker is required to enhance the accuracy of disease prediction, provide novel insights into pathophysiology and contribute to future prevention of T2DM. Various newer diagnostic methods have been developed by targeting endogenous proteins among which Adipsin is one of the promising target. Therefore, this review discusses Adipsin as a potential biomarker and its implication in T2DM. Adipsin is one of the adipokines secreted by adipose tissues which is involved in maintaining adipose tissue homeostasis and increasing insulin secretion in response to glucose. According to different experimental and clinical studies, plasma Adipsin concentrations are low in animals and patients with DM which support its use as a biomarker in combination to the other diagnostic modalities for DM. Additionally, the existence of Adipsin could be important in improving hyperglycemia by preserving β-cell mass through improving β-cell survival and maintaining their transcriptional identity.Keywords: adipsin, type 2 diabetes mellitus, biomarkerTafere GGWondafrash DZZewdie KAAssefa BTAyza MADove Medical Pressarticleadipsintype2 diabetes mellitusbiomarkerSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1855-1861 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipsin type2 diabetes mellitus biomarker Specialties of internal medicine RC581-951
spellingShingle	adipsin type2 diabetes mellitus biomarker Specialties of internal medicine RC581-951 Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
description	Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin TafereDepartment of Pharmacology and Toxicology,School of Pharmacy, Mekelle University, P.O. Box: 1871, Mekelle, EthiopiaTel +251 908822323Email gebrehiwotg07@gmail.comAbstract: Diabetes mellitus (DM) is a worldwide health threat affecting millions of people, which is associated with different micro- and macro-vascular complications. Type 2 diabetes mellitus (T2DM) is one of the different types of DM caused by insulin resistance and/or reduced secretion of insulin from the pancreas. A validated novel biomarker is required to enhance the accuracy of disease prediction, provide novel insights into pathophysiology and contribute to future prevention of T2DM. Various newer diagnostic methods have been developed by targeting endogenous proteins among which Adipsin is one of the promising target. Therefore, this review discusses Adipsin as a potential biomarker and its implication in T2DM. Adipsin is one of the adipokines secreted by adipose tissues which is involved in maintaining adipose tissue homeostasis and increasing insulin secretion in response to glucose. According to different experimental and clinical studies, plasma Adipsin concentrations are low in animals and patients with DM which support its use as a biomarker in combination to the other diagnostic modalities for DM. Additionally, the existence of Adipsin could be important in improving hyperglycemia by preserving β-cell mass through improving β-cell survival and maintaining their transcriptional identity.Keywords: adipsin, type 2 diabetes mellitus, biomarker
format	article
author	Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA
author_facet	Tafere GG Wondafrash DZ Zewdie KA Assefa BT Ayza MA
author_sort	Tafere GG
title	Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
title_short	Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
title_full	Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
title_fullStr	Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
title_full_unstemmed	Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus
title_sort	plasma adipsin as a biomarker and its implication in type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/169c311a190547a9b9cc3b5da5b28bda
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Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus

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