Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis

Liver fibrosis is a common feature of chronic liver disease. Activated hepatic stellate cells (HSCs) are the main drivers of extracellular matrix accumulation in liver fibrosis. Hence, a strategy for regulating HSC activation is crucial in treating liver fibrosis. Mesenchymal stem cells (MSCs) are m...

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Autores principales:	Chanbin Lee, Minju Kim, Jinsol Han, Myunghee Yoon, Youngmi Jung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatic stellate cells liver fibrosis mesenchymal stem cells cell-free therapy extracellular vesicles Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/169f32cd9ea44c66b8083bd2e8f06d90
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spelling	oai:doaj.org-article:169f32cd9ea44c66b8083bd2e8f06d902021-11-25T16:49:28ZMesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis10.3390/biomedicines91115982227-9059https://doaj.org/article/169f32cd9ea44c66b8083bd2e8f06d902021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1598https://doaj.org/toc/2227-9059Liver fibrosis is a common feature of chronic liver disease. Activated hepatic stellate cells (HSCs) are the main drivers of extracellular matrix accumulation in liver fibrosis. Hence, a strategy for regulating HSC activation is crucial in treating liver fibrosis. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from various post-natal organs. Therapeutic approaches involving MSCs have been studied extensively in various diseases, including liver disease. MSCs modulate hepatic inflammation and fibrosis and/or differentiate into hepatocytes by interacting directly with immune cells, HSCs, and hepatocytes and secreting modulators, thereby contributing to reduced liver fibrosis. Cell-free therapy including MSC-released secretomes and extracellular vesicles has elicited extensive attention because they could overcome MSC transplantation limitations. Herein, we provide basic information on hepatic fibrogenesis and the therapeutic potential of MSCs. We also review findings presenting the effects of MSC itself and MSC-based cell-free treatments in liver fibrosis, focusing on HSC activation. Growing evidence supports the anti-fibrotic function of either MSC itself or MSC modulators, although the mechanism underpinning their effects on liver fibrosis has not been established. Further studies are required to investigate the detailed mechanism explaining their functions to expand MSC therapies using the cell itself and cell-free treatments for liver fibrosis.Chanbin LeeMinju KimJinsol HanMyunghee YoonYoungmi JungMDPI AGarticlehepatic stellate cellsliver fibrosismesenchymal stem cellscell-free therapyextracellular vesiclesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1598, p 1598 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatic stellate cells liver fibrosis mesenchymal stem cells cell-free therapy extracellular vesicles Biology (General) QH301-705.5
spellingShingle	hepatic stellate cells liver fibrosis mesenchymal stem cells cell-free therapy extracellular vesicles Biology (General) QH301-705.5 Chanbin Lee Minju Kim Jinsol Han Myunghee Yoon Youngmi Jung Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
description	Liver fibrosis is a common feature of chronic liver disease. Activated hepatic stellate cells (HSCs) are the main drivers of extracellular matrix accumulation in liver fibrosis. Hence, a strategy for regulating HSC activation is crucial in treating liver fibrosis. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from various post-natal organs. Therapeutic approaches involving MSCs have been studied extensively in various diseases, including liver disease. MSCs modulate hepatic inflammation and fibrosis and/or differentiate into hepatocytes by interacting directly with immune cells, HSCs, and hepatocytes and secreting modulators, thereby contributing to reduced liver fibrosis. Cell-free therapy including MSC-released secretomes and extracellular vesicles has elicited extensive attention because they could overcome MSC transplantation limitations. Herein, we provide basic information on hepatic fibrogenesis and the therapeutic potential of MSCs. We also review findings presenting the effects of MSC itself and MSC-based cell-free treatments in liver fibrosis, focusing on HSC activation. Growing evidence supports the anti-fibrotic function of either MSC itself or MSC modulators, although the mechanism underpinning their effects on liver fibrosis has not been established. Further studies are required to investigate the detailed mechanism explaining their functions to expand MSC therapies using the cell itself and cell-free treatments for liver fibrosis.
format	article
author	Chanbin Lee Minju Kim Jinsol Han Myunghee Yoon Youngmi Jung
author_facet	Chanbin Lee Minju Kim Jinsol Han Myunghee Yoon Youngmi Jung
author_sort	Chanbin Lee
title	Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
title_short	Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
title_full	Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
title_fullStr	Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
title_full_unstemmed	Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis
title_sort	mesenchymal stem cells influence activation of hepatic stellate cells, and constitute a promising therapy for liver fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/169f32cd9ea44c66b8083bd2e8f06d90
work_keys_str_mv	AT chanbinlee mesenchymalstemcellsinfluenceactivationofhepaticstellatecellsandconstituteapromisingtherapyforliverfibrosis AT minjukim mesenchymalstemcellsinfluenceactivationofhepaticstellatecellsandconstituteapromisingtherapyforliverfibrosis AT jinsolhan mesenchymalstemcellsinfluenceactivationofhepaticstellatecellsandconstituteapromisingtherapyforliverfibrosis AT myungheeyoon mesenchymalstemcellsinfluenceactivationofhepaticstellatecellsandconstituteapromisingtherapyforliverfibrosis AT youngmijung mesenchymalstemcellsinfluenceactivationofhepaticstellatecellsandconstituteapromisingtherapyforliverfibrosis
_version_	1718412878992637952

Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis

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