Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which c...
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Nature Portfolio
2020
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oai:doaj.org-article:169f3fde02b44f04a44160ad8fb944192021-12-02T17:33:13ZDeep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains10.1038/s41467-020-19334-32041-1723https://doaj.org/article/169f3fde02b44f04a44160ad8fb944192020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19334-3https://doaj.org/toc/2041-1723Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which could improve oncology decisions in under-resourced settings.Nikhil NaikAli MadaniAndre EstevaNitish Shirish KeskarMichael F. PressDaniel RudermanDavid B. AgusRichard SocherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
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Science Q Nikhil Naik Ali Madani Andre Esteva Nitish Shirish Keskar Michael F. Press Daniel Ruderman David B. Agus Richard Socher Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
description |
Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which could improve oncology decisions in under-resourced settings. |
format |
article |
author |
Nikhil Naik Ali Madani Andre Esteva Nitish Shirish Keskar Michael F. Press Daniel Ruderman David B. Agus Richard Socher |
author_facet |
Nikhil Naik Ali Madani Andre Esteva Nitish Shirish Keskar Michael F. Press Daniel Ruderman David B. Agus Richard Socher |
author_sort |
Nikhil Naik |
title |
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
title_short |
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
title_full |
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
title_fullStr |
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
title_full_unstemmed |
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains |
title_sort |
deep learning-enabled breast cancer hormonal receptor status determination from base-level h&e stains |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/169f3fde02b44f04a44160ad8fb94419 |
work_keys_str_mv |
AT nikhilnaik deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT alimadani deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT andreesteva deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT nitishshirishkeskar deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT michaelfpress deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT danielruderman deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT davidbagus deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains AT richardsocher deeplearningenabledbreastcancerhormonalreceptorstatusdeterminationfrombaselevelhestains |
_version_ |
1718379985666834432 |