Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains

Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which c...

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Autores principales: Nikhil Naik, Ali Madani, Andre Esteva, Nitish Shirish Keskar, Michael F. Press, Daniel Ruderman, David B. Agus, Richard Socher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/169f3fde02b44f04a44160ad8fb94419
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spelling oai:doaj.org-article:169f3fde02b44f04a44160ad8fb944192021-12-02T17:33:13ZDeep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains10.1038/s41467-020-19334-32041-1723https://doaj.org/article/169f3fde02b44f04a44160ad8fb944192020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19334-3https://doaj.org/toc/2041-1723Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which could improve oncology decisions in under-resourced settings.Nikhil NaikAli MadaniAndre EstevaNitish Shirish KeskarMichael F. PressDaniel RudermanDavid B. AgusRichard SocherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nikhil Naik
Ali Madani
Andre Esteva
Nitish Shirish Keskar
Michael F. Press
Daniel Ruderman
David B. Agus
Richard Socher
Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
description Determination of estrogen receptor status (ERS) in breast cancer tissue requires immunohistochemistry, which is sensitive to the vagaries of sample processing and the subjectivity of pathologists. Here the authors present a deep learning model that determines ERS from H&E stained tissue, which could improve oncology decisions in under-resourced settings.
format article
author Nikhil Naik
Ali Madani
Andre Esteva
Nitish Shirish Keskar
Michael F. Press
Daniel Ruderman
David B. Agus
Richard Socher
author_facet Nikhil Naik
Ali Madani
Andre Esteva
Nitish Shirish Keskar
Michael F. Press
Daniel Ruderman
David B. Agus
Richard Socher
author_sort Nikhil Naik
title Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
title_short Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
title_full Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
title_fullStr Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
title_full_unstemmed Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains
title_sort deep learning-enabled breast cancer hormonal receptor status determination from base-level h&e stains
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/169f3fde02b44f04a44160ad8fb94419
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