Biomimetic cellulose-based superabsorbent hydrogels for treating obesity

Abstract In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SA...

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Autores principales:	Marta Madaghiele, Christian Demitri, Ivo Surano, Alessandra Silvestri, Milena Vitale, Eliana Panteca, Yishai Zohar, Maria Rescigno, Alessandro Sannino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/169fb92411fc412bbb3a596c2d8ff632
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spelling	oai:doaj.org-article:169fb92411fc412bbb3a596c2d8ff6322021-11-08T10:48:07ZBiomimetic cellulose-based superabsorbent hydrogels for treating obesity10.1038/s41598-021-00884-52045-2322https://doaj.org/article/169fb92411fc412bbb3a596c2d8ff6322021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00884-5https://doaj.org/toc/2045-2322Abstract In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SAH) platform, inspired by the composition and mechanical properties of raw vegetables, as a mechanobiological therapy. The CB-SAHs properties were studied in a simulated gastrointestinal environment, while their impact on gut tissue was investigated by an ex vivo organ culture (EVOC) model. Functional fibers and raw vegetables were used as reference. CB-SAHs demonstrated orders of magnitude higher elasticity in comparison to the tested functional fibers, however performed similar to the tested raw vegetables. Notably, the biomimetic CB-SAHs with elasticity levels similar to raw vegetables showed benefits in preserving and regulating the gut tissue in the EVOC model. Non-systemic oral mechanotherapeutics based on this technology were advanced through clinical studies, with a first product cleared as an aid for weight management in the US and Europe.Marta MadaghieleChristian DemitriIvo SuranoAlessandra SilvestriMilena VitaleEliana PantecaYishai ZoharMaria RescignoAlessandro SanninoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Madaghiele Christian Demitri Ivo Surano Alessandra Silvestri Milena Vitale Eliana Panteca Yishai Zohar Maria Rescigno Alessandro Sannino Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
description	Abstract In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain. Since vegetable consumption is a fundamental part of many dietary interventions and daily nutrient requirements, we developed a novel cellulose-based superabsorbent hydrogel (CB-SAH) platform, inspired by the composition and mechanical properties of raw vegetables, as a mechanobiological therapy. The CB-SAHs properties were studied in a simulated gastrointestinal environment, while their impact on gut tissue was investigated by an ex vivo organ culture (EVOC) model. Functional fibers and raw vegetables were used as reference. CB-SAHs demonstrated orders of magnitude higher elasticity in comparison to the tested functional fibers, however performed similar to the tested raw vegetables. Notably, the biomimetic CB-SAHs with elasticity levels similar to raw vegetables showed benefits in preserving and regulating the gut tissue in the EVOC model. Non-systemic oral mechanotherapeutics based on this technology were advanced through clinical studies, with a first product cleared as an aid for weight management in the US and Europe.
format	article
author	Marta Madaghiele Christian Demitri Ivo Surano Alessandra Silvestri Milena Vitale Eliana Panteca Yishai Zohar Maria Rescigno Alessandro Sannino
author_facet	Marta Madaghiele Christian Demitri Ivo Surano Alessandra Silvestri Milena Vitale Eliana Panteca Yishai Zohar Maria Rescigno Alessandro Sannino
author_sort	Marta Madaghiele
title	Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_short	Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_full	Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_fullStr	Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_full_unstemmed	Biomimetic cellulose-based superabsorbent hydrogels for treating obesity
title_sort	biomimetic cellulose-based superabsorbent hydrogels for treating obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/169fb92411fc412bbb3a596c2d8ff632
work_keys_str_mv	AT martamadaghiele biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT christiandemitri biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT ivosurano biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT alessandrasilvestri biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT milenavitale biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT elianapanteca biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT yishaizohar biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT mariarescigno biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity AT alessandrosannino biomimeticcellulosebasedsuperabsorbenthydrogelsfortreatingobesity
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Biomimetic cellulose-based superabsorbent hydrogels for treating obesity

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