Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel

Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omeg...

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Autores principales:	S. A. Rice, M. Mikes, D. Bibus, E. Berdyshev, J. A. Reisz, S. Gehrke, I. Bronova, A. D’Alessandro, K. L. Drew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7
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spelling	oai:doaj.org-article:16a6e30838bf46f0b6f8290857fdbda72021-12-02T14:12:47ZOmega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel10.1038/s41598-020-78763-82045-2322https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78763-8https://doaj.org/toc/2045-2322Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omega 3 PUFA, termed Balanced Diet), or an omega 6:3 ratio of 5:1 (Standard Rodent Chow), and measured the influence of diet on core body temperature (Tb), brown adipose tissue (BAT) mass, fatty acid profiles of BAT, white adipose tissue (WAT) and plasma as well as hypothalamic endocannabinoid and endocannabinoid-like bioactive fatty acid amides during hibernation. Results show feeding a diet high in omega 3 PUFAs, with a more balanced omega 6:3 ratio, increases AGS Tb in torpor. We found the diet-induced increase in Tb during torpor is most easily explained by an increase in the mass of BAT deposits of Balanced Diet AGS. The increase in BAT mass is associated with elevated levels of metabolites DHA and EPA in tissue and plasma suggesting that these omega 3 PUFAs may play a role in thermogenesis during torpor. While we did not observe diet-induced change in endocannabinoids, we do report altered hypothalamic levels of some endocannabinoids, and endocannabinoid-like compounds, during hibernation.S. A. RiceM. MikesD. BibusE. BerdyshevJ. A. ReiszS. GehrkeI. BronovaA. D’AlessandroK. L. DrewNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
description	Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omega 3 PUFA, termed Balanced Diet), or an omega 6:3 ratio of 5:1 (Standard Rodent Chow), and measured the influence of diet on core body temperature (Tb), brown adipose tissue (BAT) mass, fatty acid profiles of BAT, white adipose tissue (WAT) and plasma as well as hypothalamic endocannabinoid and endocannabinoid-like bioactive fatty acid amides during hibernation. Results show feeding a diet high in omega 3 PUFAs, with a more balanced omega 6:3 ratio, increases AGS Tb in torpor. We found the diet-induced increase in Tb during torpor is most easily explained by an increase in the mass of BAT deposits of Balanced Diet AGS. The increase in BAT mass is associated with elevated levels of metabolites DHA and EPA in tissue and plasma suggesting that these omega 3 PUFAs may play a role in thermogenesis during torpor. While we did not observe diet-induced change in endocannabinoids, we do report altered hypothalamic levels of some endocannabinoids, and endocannabinoid-like compounds, during hibernation.
format	article
author	S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew
author_facet	S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew
author_sort	S. A. Rice
title	Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
title_short	Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
title_full	Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
title_fullStr	Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
title_full_unstemmed	Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
title_sort	omega 3 fatty acids stimulate thermogenesis during torpor in the arctic ground squirrel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7
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Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel

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