The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2
Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and...
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Endocrinology Research Centre
2012
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oai:doaj.org-article:16a6f6d30a694c4f8d52b3756719cbc52021-11-14T09:00:17ZThe role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 22072-03512072-037810.14341/2072-0351-5976https://doaj.org/article/16a6f6d30a694c4f8d52b3756719cbc52012-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5976https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.Yulia Valer'evna KhasanovaAlsu Asatovna NelaevaAnna Borisovna GalkinaIrina Vasil'evna MedvedevaEndocrinology Research Centrearticlediabetes mellitus type 2diabetic nephropathychronic kidney diseasecoagulopathyiterleikin-6homocysteininflammationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 1, Pp 31-34 (2012) |
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DOAJ |
| collection |
DOAJ |
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EN RU |
| topic |
diabetes mellitus type 2 diabetic nephropathy chronic kidney disease coagulopathy iterleikin-6 homocystein inflammation Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
diabetes mellitus type 2 diabetic nephropathy chronic kidney disease coagulopathy iterleikin-6 homocystein inflammation Nutritional diseases. Deficiency diseases RC620-627 Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| description |
Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM. |
| format |
article |
| author |
Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva |
| author_facet |
Yulia Valer'evna Khasanova Alsu Asatovna Nelaeva Anna Borisovna Galkina Irina Vasil'evna Medvedeva |
| author_sort |
Yulia Valer'evna Khasanova |
| title |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_short |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_full |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_fullStr |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_full_unstemmed |
The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| title_sort |
role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2 |
| publisher |
Endocrinology Research Centre |
| publishDate |
2012 |
| url |
https://doaj.org/article/16a6f6d30a694c4f8d52b3756719cbc5 |
| work_keys_str_mv |
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