Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?

Genetic predisposition could have an important role in the pathogenesis of cancers in children and adolescents. A recent study by our group showed that, among female survivors of cancers in childhood and adolescence, the proportion of cases involving a possible genetic predisposition was sizable (at...

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Autores principales:	Francesca Filippi, Fedro Peccatori, Siranoush Manoukian, Carlo Alfredo Clerici, Chiara Dallagiovanna, Cristina Meazza, Marta Podda, Edgardo Somigliana, Filippo Spreafico, Maura Massimino, Monica Terenziani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hereditary cancer syndrome cancer survivors fertility preservation genetics infertility preimplantation genetic testing Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/16a84537a2044c92b2638d051f67ae43
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spelling	oai:doaj.org-article:16a84537a2044c92b2638d051f67ae432021-11-25T17:01:47ZFertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?10.3390/cancers132256262072-6694https://doaj.org/article/16a84537a2044c92b2638d051f67ae432021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5626https://doaj.org/toc/2072-6694Genetic predisposition could have an important role in the pathogenesis of cancers in children and adolescents. A recent study by our group showed that, among female survivors of cancers in childhood and adolescence, the proportion of cases involving a possible genetic predisposition was sizable (at least one in five). Our sample is too small to be representative of the general population, but it gave us an opportunity to reappraise this issue. Women with a genetic predisposition can transmit the risk of cancer to their offspring, and their awareness of this may influence their reproductive and fertility preservation choices. In our experience, a predisposition to cancer receives little attention in the fertility counseling and decision-making process unless a patient already has a definitive molecular diagnosis of a hereditary cancer syndrome. We feel it is essential to empower women on this issue, particularly as there are ways to overcome the problem, including preimplantation genetic testing (PGT-M) in definitively diagnosed cases, egg donation and adoption. In the context of fertility counseling for survivors of cancer in childhood and adolescence who have reached adulthood, the risk of transmitting a predisposition to cancer should be discussed with patients, if relevant and desired.Francesca FilippiFedro PeccatoriSiranoush ManoukianCarlo Alfredo ClericiChiara DallagiovannaCristina MeazzaMarta PoddaEdgardo SomiglianaFilippo SpreaficoMaura MassiminoMonica TerenzianiMDPI AGarticlehereditary cancer syndromecancer survivorsfertility preservationgeneticsinfertilitypreimplantation genetic testingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5626, p 5626 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hereditary cancer syndrome cancer survivors fertility preservation genetics infertility preimplantation genetic testing Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hereditary cancer syndrome cancer survivors fertility preservation genetics infertility preimplantation genetic testing Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Francesca Filippi Fedro Peccatori Siranoush Manoukian Carlo Alfredo Clerici Chiara Dallagiovanna Cristina Meazza Marta Podda Edgardo Somigliana Filippo Spreafico Maura Massimino Monica Terenziani Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
description	Genetic predisposition could have an important role in the pathogenesis of cancers in children and adolescents. A recent study by our group showed that, among female survivors of cancers in childhood and adolescence, the proportion of cases involving a possible genetic predisposition was sizable (at least one in five). Our sample is too small to be representative of the general population, but it gave us an opportunity to reappraise this issue. Women with a genetic predisposition can transmit the risk of cancer to their offspring, and their awareness of this may influence their reproductive and fertility preservation choices. In our experience, a predisposition to cancer receives little attention in the fertility counseling and decision-making process unless a patient already has a definitive molecular diagnosis of a hereditary cancer syndrome. We feel it is essential to empower women on this issue, particularly as there are ways to overcome the problem, including preimplantation genetic testing (PGT-M) in definitively diagnosed cases, egg donation and adoption. In the context of fertility counseling for survivors of cancer in childhood and adolescence who have reached adulthood, the risk of transmitting a predisposition to cancer should be discussed with patients, if relevant and desired.
format	article
author	Francesca Filippi Fedro Peccatori Siranoush Manoukian Carlo Alfredo Clerici Chiara Dallagiovanna Cristina Meazza Marta Podda Edgardo Somigliana Filippo Spreafico Maura Massimino Monica Terenziani
author_facet	Francesca Filippi Fedro Peccatori Siranoush Manoukian Carlo Alfredo Clerici Chiara Dallagiovanna Cristina Meazza Marta Podda Edgardo Somigliana Filippo Spreafico Maura Massimino Monica Terenziani
author_sort	Francesca Filippi
title	Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
title_short	Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
title_full	Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
title_fullStr	Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
title_full_unstemmed	Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?
title_sort	fertility counseling in survivors of cancer in childhood and adolescence: time for a reappraisal?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16a84537a2044c92b2638d051f67ae43
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Fertility Counseling in Survivors of Cancer in Childhood and Adolescence: Time for a Reappraisal?

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