Structure of the human marker of self 5-transmembrane receptor CD47
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.
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Nature Portfolio
2021
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oai:doaj.org-article:16ac1202277e490cac61cc68b1c66fb72021-12-02T15:26:52ZStructure of the human marker of self 5-transmembrane receptor CD4710.1038/s41467-021-25475-w2041-1723https://doaj.org/article/16ac1202277e490cac61cc68b1c66fb72021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25475-whttps://doaj.org/toc/2041-1723CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.Gustavo FenaltiNicolas VillanuevaMark GriffithBarbra PagariganSirish Kaushik LakkarajuRichard Y.-C. HuangNadia LadyginaAlok SharmaDavid MikolonMahan AbbasianJeffrey JohnsonHaralambos HadjivassiliouDan ZhuPhilip P. ChamberlainHo ChoKandasamy HariharanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan Structure of the human marker of self 5-transmembrane receptor CD47 |
| description |
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling. |
| format |
article |
| author |
Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan |
| author_facet |
Gustavo Fenalti Nicolas Villanueva Mark Griffith Barbra Pagarigan Sirish Kaushik Lakkaraju Richard Y.-C. Huang Nadia Ladygina Alok Sharma David Mikolon Mahan Abbasian Jeffrey Johnson Haralambos Hadjivassiliou Dan Zhu Philip P. Chamberlain Ho Cho Kandasamy Hariharan |
| author_sort |
Gustavo Fenalti |
| title |
Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_short |
Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_full |
Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_fullStr |
Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_full_unstemmed |
Structure of the human marker of self 5-transmembrane receptor CD47 |
| title_sort |
structure of the human marker of self 5-transmembrane receptor cd47 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/16ac1202277e490cac61cc68b1c66fb7 |
| work_keys_str_mv |
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