Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients

Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and magnesium (Mg) in patients with type 2 diabetes mell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jehan A. Mohammad, Ammar A. Y. Almulathanon, Fatimah Haitham Fathi
Formato:	article
Lenguaje:	EN
Publicado:	Pensoft Publishers 2021
Materias:	Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/16ad3f1139a14323883e8d49d7665cb3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16ad3f1139a14323883e8d49d7665cb3
record_format	dspace
spelling	oai:doaj.org-article:16ad3f1139a14323883e8d49d7665cb32021-11-12T04:31:00ZAssessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients10.3897/pharmacia.68.e720802603-557Xhttps://doaj.org/article/16ad3f1139a14323883e8d49d7665cb32021-11-01T00:00:00Zhttps://pharmacia.pensoft.net/article/72080/download/pdf/https://pharmacia.pensoft.net/article/72080/download/xml/https://pharmacia.pensoft.net/article/72080/https://doaj.org/toc/2603-557XMetformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and magnesium (Mg) in patients with type 2 diabetes mellitus. The metformin-treated patients showed significantly lower serum Cu levels compared with the untreated and glibenclamide groups. In addition, treatment with metformin was associated with a significant increase in serum concentrations of Zn compared to the newly diagnosed patients, whereas it did not show a noticeable alteration in the serum level of Mg. In contrast, the glibenclamide treated group revealed significantly higher Zn and Mg levels compared with the newly diagnosed group, while the serum level of Cu was not significantly modified. In conclusion, treatment with metformin led to a reduction in serum Cu and an increase in serum Zn concentrations, whereas glibenclamide treatment displayed enhancement in serum Zn and Mg levels.Jehan A. MohammadAmmar A. Y. AlmulathanonFatimah Haitham FathiPensoft PublishersarticlePharmacy and materia medicaRS1-441ENPharmacia, Vol 68, Iss 4, Pp 845-849 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pharmacy and materia medica RS1-441
spellingShingle	Pharmacy and materia medica RS1-441 Jehan A. Mohammad Ammar A. Y. Almulathanon Fatimah Haitham Fathi Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
description	Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and magnesium (Mg) in patients with type 2 diabetes mellitus. The metformin-treated patients showed significantly lower serum Cu levels compared with the untreated and glibenclamide groups. In addition, treatment with metformin was associated with a significant increase in serum concentrations of Zn compared to the newly diagnosed patients, whereas it did not show a noticeable alteration in the serum level of Mg. In contrast, the glibenclamide treated group revealed significantly higher Zn and Mg levels compared with the newly diagnosed group, while the serum level of Cu was not significantly modified. In conclusion, treatment with metformin led to a reduction in serum Cu and an increase in serum Zn concentrations, whereas glibenclamide treatment displayed enhancement in serum Zn and Mg levels.
format	article
author	Jehan A. Mohammad Ammar A. Y. Almulathanon Fatimah Haitham Fathi
author_facet	Jehan A. Mohammad Ammar A. Y. Almulathanon Fatimah Haitham Fathi
author_sort	Jehan A. Mohammad
title	Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
title_short	Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
title_full	Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
title_fullStr	Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
title_full_unstemmed	Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
title_sort	assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients
publisher	Pensoft Publishers
publishDate	2021
url	https://doaj.org/article/16ad3f1139a14323883e8d49d7665cb3
work_keys_str_mv	AT jehanamohammad assessmentoftheeffectsofmetforminandglibenclamideontheconcentrationofselectedtraceelementsintype2diabeticpatients AT ammarayalmulathanon assessmentoftheeffectsofmetforminandglibenclamideontheconcentrationofselectedtraceelementsintype2diabeticpatients AT fatimahhaithamfathi assessmentoftheeffectsofmetforminandglibenclamideontheconcentrationofselectedtraceelementsintype2diabeticpatients
_version_	1718431273689546752

Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients

Ejemplares similares