<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
The invertebrate model, <i>Galleria mellonella</i>, has been widely used to study host–pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. <i>G. mellonella</i> larvae have been proven to be useful and a reliable model for...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/16b055c5e3b54a47bf2e6300493ee48a |
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| Sumario: | The invertebrate model, <i>Galleria mellonella</i>, has been widely used to study host–pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. <i>G. mellonella</i> larvae have been proven to be useful and a reliable model for analyzing pathogenesis mechanisms of multidrug resistant <i>Acinetobacter baumannii,</i> an opportunistic pathogen difficult to kill. This review describes the detailed experimental design of <i>G. mellonella</i>/<i>A. baumannii</i> models, and provides a comprehensive comparison of various virulence factors and therapy strategies using the <i>G. mellonella</i> host. These investigations highlight the importance of this host–pathogen model for in vivo pathogen virulence studies. On the long term, further development of the <i>G. mellonella</i>/<i>A. baumannii</i> model will offer promising insights for clinical treatments of <i>A. baumannii</i> infection. |
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