Galleria mellonella as a Good Model to Study Acinetobacter baumannii Pathogenesis

The invertebrate model, Galleria mellonella, has been widely used to study host–pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. G. mellonella larvae have been proven to be useful and a reliable model for...

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Autores principales:	Ye Tao, Luminita Duma, Yannick Rossez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Acinetobacter baumannii</i> <i>Galleria mellonella</i> host–pathogen interactions virulence factors therapy strategies Medicine R
Acceso en línea:	https://doaj.org/article/16b055c5e3b54a47bf2e6300493ee48a
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spelling	oai:doaj.org-article:16b055c5e3b54a47bf2e6300493ee48a2021-11-25T18:38:36Z<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis10.3390/pathogens101114832076-0817https://doaj.org/article/16b055c5e3b54a47bf2e6300493ee48a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1483https://doaj.org/toc/2076-0817The invertebrate model, <i>Galleria mellonella</i>, has been widely used to study host–pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. <i>G. mellonella</i> larvae have been proven to be useful and a reliable model for analyzing pathogenesis mechanisms of multidrug resistant <i>Acinetobacter baumannii,</i> an opportunistic pathogen difficult to kill. This review describes the detailed experimental design of <i>G. mellonella</i>/<i>A. baumannii</i> models, and provides a comprehensive comparison of various virulence factors and therapy strategies using the <i>G. mellonella</i> host. These investigations highlight the importance of this host–pathogen model for in vivo pathogen virulence studies. On the long term, further development of the <i>G. mellonella</i>/<i>A. baumannii</i> model will offer promising insights for clinical treatments of <i>A. baumannii</i> infection.Ye TaoLuminita DumaYannick RossezMDPI AGarticle<i>Acinetobacter baumannii</i><i>Galleria mellonella</i>host–pathogen interactionsvirulence factorstherapy strategiesMedicineRENPathogens, Vol 10, Iss 1483, p 1483 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Acinetobacter baumannii</i> <i>Galleria mellonella</i> host–pathogen interactions virulence factors therapy strategies Medicine R
spellingShingle	<i>Acinetobacter baumannii</i> <i>Galleria mellonella</i> host–pathogen interactions virulence factors therapy strategies Medicine R Ye Tao Luminita Duma Yannick Rossez <i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
description	The invertebrate model, <i>Galleria mellonella</i>, has been widely used to study host–pathogen interactions due to its cheapness, ease of handling, and similar mammalian innate immune system. <i>G. mellonella</i> larvae have been proven to be useful and a reliable model for analyzing pathogenesis mechanisms of multidrug resistant <i>Acinetobacter baumannii,</i> an opportunistic pathogen difficult to kill. This review describes the detailed experimental design of <i>G. mellonella</i>/<i>A. baumannii</i> models, and provides a comprehensive comparison of various virulence factors and therapy strategies using the <i>G. mellonella</i> host. These investigations highlight the importance of this host–pathogen model for in vivo pathogen virulence studies. On the long term, further development of the <i>G. mellonella</i>/<i>A. baumannii</i> model will offer promising insights for clinical treatments of <i>A. baumannii</i> infection.
format	article
author	Ye Tao Luminita Duma Yannick Rossez
author_facet	Ye Tao Luminita Duma Yannick Rossez
author_sort	Ye Tao
title	<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
title_short	<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
title_full	<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
title_fullStr	<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
title_full_unstemmed	<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis
title_sort	<i>galleria mellonella</i> as a good model to study <i>acinetobacter baumannii</i> pathogenesis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/16b055c5e3b54a47bf2e6300493ee48a
work_keys_str_mv	AT yetao igalleriamellonellaiasagoodmodeltostudyiacinetobacterbaumanniiipathogenesis AT luminitaduma igalleriamellonellaiasagoodmodeltostudyiacinetobacterbaumanniiipathogenesis AT yannickrossez igalleriamellonellaiasagoodmodeltostudyiacinetobacterbaumanniiipathogenesis
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<i>Galleria mellonella</i> as a Good Model to Study <i>Acinetobacter baumannii</i> Pathogenesis

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