Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation

A major question in redox signaling is how H2O2 oxidizes target protein thiols in the presence of glutathione peroxidases and peroxiredoxins. We reveal signaling by H2O2 via its enzymatic conversion to an alkyl hydroperoxide that stereo-specifically escapes peroxidases and oxidizes target proteins.

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Autores principales:	Raphael F. Queiroz, Christopher P. Stanley, Kathryn Wolhuter, Stephanie M. Y. Kong, Ragul Rajivan, Naomi McKinnon, Giang T. H. Nguyen, Antonella Roveri, Sebastian Guttzeit, Philip Eaton, William A. Donald, Fulvio Ursini, Christine C. Winterbourn, Anita Ayer, Roland Stocker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
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spelling	oai:doaj.org-article:16b1acb3e2684793a89d03d6d3dc92b42021-11-21T12:34:06ZHydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation10.1038/s41467-021-26991-52041-1723https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26991-5https://doaj.org/toc/2041-1723A major question in redox signaling is how H2O2 oxidizes target protein thiols in the presence of glutathione peroxidases and peroxiredoxins. We reveal signaling by H2O2 via its enzymatic conversion to an alkyl hydroperoxide that stereo-specifically escapes peroxidases and oxidizes target proteins.Raphael F. QueirozChristopher P. StanleyKathryn WolhuterStephanie M. Y. KongRagul RajivanNaomi McKinnonGiang T. H. NguyenAntonella RoveriSebastian GuttzeitPhilip EatonWilliam A. DonaldFulvio UrsiniChristine C. WinterbournAnita AyerRoland StockerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphael F. Queiroz Christopher P. Stanley Kathryn Wolhuter Stephanie M. Y. Kong Ragul Rajivan Naomi McKinnon Giang T. H. Nguyen Antonella Roveri Sebastian Guttzeit Philip Eaton William A. Donald Fulvio Ursini Christine C. Winterbourn Anita Ayer Roland Stocker Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
description	A major question in redox signaling is how H2O2 oxidizes target protein thiols in the presence of glutathione peroxidases and peroxiredoxins. We reveal signaling by H2O2 via its enzymatic conversion to an alkyl hydroperoxide that stereo-specifically escapes peroxidases and oxidizes target proteins.
format	article
author	Raphael F. Queiroz Christopher P. Stanley Kathryn Wolhuter Stephanie M. Y. Kong Ragul Rajivan Naomi McKinnon Giang T. H. Nguyen Antonella Roveri Sebastian Guttzeit Philip Eaton William A. Donald Fulvio Ursini Christine C. Winterbourn Anita Ayer Roland Stocker
author_facet	Raphael F. Queiroz Christopher P. Stanley Kathryn Wolhuter Stephanie M. Y. Kong Ragul Rajivan Naomi McKinnon Giang T. H. Nguyen Antonella Roveri Sebastian Guttzeit Philip Eaton William A. Donald Fulvio Ursini Christine C. Winterbourn Anita Ayer Roland Stocker
author_sort	Raphael F. Queiroz
title	Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
title_short	Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
title_full	Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
title_fullStr	Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
title_full_unstemmed	Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
title_sort	hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
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Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation

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