The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine

Abstract In the present experiment, it was assumed that the appropriate dietary ratio of arginine (Arg) to lysine (Lys) can improve the immune status and growth performance of turkeys. The aim of this study was to evaluate the effects of two inclusion rates of Arg relative to Lys in turkey diets wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katarzyna Ognik, Dariusz Mikulski, Paweł Konieczka, Bartłomiej Tykałowski, Magdalena Krauze, Anna Stępniowska, Anna Nynca, Jan Jankowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16b59496290d4fb39166936bb744a0ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16b59496290d4fb39166936bb744a0ca
record_format	dspace
spelling	oai:doaj.org-article:16b59496290d4fb39166936bb744a0ca2021-12-02T18:49:30ZThe immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine10.1038/s41598-021-95529-y2045-2322https://doaj.org/article/16b59496290d4fb39166936bb744a0ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95529-yhttps://doaj.org/toc/2045-2322Abstract In the present experiment, it was assumed that the appropriate dietary ratio of arginine (Arg) to lysine (Lys) can improve the immune status and growth performance of turkeys. The aim of this study was to evaluate the effects of two inclusion rates of Arg relative to Lys in turkey diets with Lys content consistent with National Research Council (NRC) recommendations or 10% higher on the immune status of birds and indicators of protein and DNA damage due to oxidation, nitration or epigenetic changes. Another goal was to determine which dietary Arg:Lys ratio stimulates the immune response of turkeys vaccinated against Ornithobacterium rhinotracheale. The experiment was performed on 576 turkeys randomly assigned to four groups with two levels of Lys (low = NRC recommendation or high = NRC + 10%) and two levels of Arg (95% or 105% Arg relative to the content of dietary Lys). It was found that the Lys content of turkey diets should be 10% higher than that recommended by the NRC and combined with the higher Arg level (105% of Lys). Although the above Arg:Lys ratio did not improve the growth performance of birds, it stimulated their immune system and reduced protein nitration as well as protein and DNA oxidation.Katarzyna OgnikDariusz MikulskiPaweł KonieczkaBartłomiej TykałowskiMagdalena KrauzeAnna StępniowskaAnna NyncaJan JankowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna Ognik Dariusz Mikulski Paweł Konieczka Bartłomiej Tykałowski Magdalena Krauze Anna Stępniowska Anna Nynca Jan Jankowski The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
description	Abstract In the present experiment, it was assumed that the appropriate dietary ratio of arginine (Arg) to lysine (Lys) can improve the immune status and growth performance of turkeys. The aim of this study was to evaluate the effects of two inclusion rates of Arg relative to Lys in turkey diets with Lys content consistent with National Research Council (NRC) recommendations or 10% higher on the immune status of birds and indicators of protein and DNA damage due to oxidation, nitration or epigenetic changes. Another goal was to determine which dietary Arg:Lys ratio stimulates the immune response of turkeys vaccinated against Ornithobacterium rhinotracheale. The experiment was performed on 576 turkeys randomly assigned to four groups with two levels of Lys (low = NRC recommendation or high = NRC + 10%) and two levels of Arg (95% or 105% Arg relative to the content of dietary Lys). It was found that the Lys content of turkey diets should be 10% higher than that recommended by the NRC and combined with the higher Arg level (105% of Lys). Although the above Arg:Lys ratio did not improve the growth performance of birds, it stimulated their immune system and reduced protein nitration as well as protein and DNA oxidation.
format	article
author	Katarzyna Ognik Dariusz Mikulski Paweł Konieczka Bartłomiej Tykałowski Magdalena Krauze Anna Stępniowska Anna Nynca Jan Jankowski
author_facet	Katarzyna Ognik Dariusz Mikulski Paweł Konieczka Bartłomiej Tykałowski Magdalena Krauze Anna Stępniowska Anna Nynca Jan Jankowski
author_sort	Katarzyna Ognik
title	The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
title_short	The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
title_full	The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
title_fullStr	The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
title_full_unstemmed	The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
title_sort	immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/16b59496290d4fb39166936bb744a0ca
work_keys_str_mv	AT katarzynaognik theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT dariuszmikulski theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT pawełkonieczka theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT bartłomiejtykałowski theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT magdalenakrauze theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT annastepniowska theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT annanynca theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT janjankowski theimmunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT katarzynaognik immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT dariuszmikulski immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT pawełkonieczka immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT bartłomiejtykałowski immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT magdalenakrauze immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT annastepniowska immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT annanynca immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine AT janjankowski immunestatusoxidativeandepigeneticchangesintissuesofturkeysfeddietswithdifferentratiosofarginineandlysine
_version_	1718377547393138688

The immune status, oxidative and epigenetic changes in tissues of turkeys fed diets with different ratios of arginine and lysine

Ejemplares similares