First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review

Infections with vancomycin-resistant enterococci (VRE) have limited treatment options, with linezolid the mainstay of therapy. The emergence of linezolid-resistant vancomycin-resistant enterococci (LRVRE) further restricts the therapeutic options. LRVRE isolated from clinical specimen have not previ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei Chuan Chua, Abdul Rahman Zaidah
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/16b62e4e6de04ed6ab0339330334f27c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16b62e4e6de04ed6ab0339330334f27c
record_format	dspace
spelling	oai:doaj.org-article:16b62e4e6de04ed6ab0339330334f27c2021-12-01T02:03:36ZFirst reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review2010-10582059-232910.1177/2010105820978666https://doaj.org/article/16b62e4e6de04ed6ab0339330334f27c2021-12-01T00:00:00Zhttps://doi.org/10.1177/2010105820978666https://doaj.org/toc/2010-1058https://doaj.org/toc/2059-2329Infections with vancomycin-resistant enterococci (VRE) have limited treatment options, with linezolid the mainstay of therapy. The emergence of linezolid-resistant vancomycin-resistant enterococci (LRVRE) further restricts the therapeutic options. LRVRE isolated from clinical specimen have not previously been reported in South-East Asia. Here, we report three clinical cases of LRVRE from a teaching hospital in Malaysia. Three isolates of Enterococcus faecium were isolated from three different patients. These isolates were determined to be resistant to both vancomycin and linezolid by Etest gradient diffusion test and Vitek2 automated antibiotic susceptibility testing, respectively. Retrospective analysis of the microbiological and clinical data of the three patients was undertaken. LRVRE were isolated from from tissue and peritoneal fluid of two patients who underwent complicated abdominal surgery. Another patient with underlying acute lymphoblastic leukaemia developed neutropenia following chemotherapy. LRVRE were isolated from the blood culture. All three patients were not treated with linezolid. The possible risk factors for LRVRE acquisition are administration of multiple broad-spectrum antimicrobials and disruption of the gastrointestinal mucosa. The appearance of LRVRE in increasingly widespread geographic locations may lead to a global health threat. Judicious use of broad-spectrum antimicrobials and infection-control practices are crucial to curb its spread.Wei Chuan ChuaAbdul Rahman ZaidahSAGE PublishingarticleMedicineRENProceedings of Singapore Healthcare, Vol 30 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Wei Chuan Chua Abdul Rahman Zaidah First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
description	Infections with vancomycin-resistant enterococci (VRE) have limited treatment options, with linezolid the mainstay of therapy. The emergence of linezolid-resistant vancomycin-resistant enterococci (LRVRE) further restricts the therapeutic options. LRVRE isolated from clinical specimen have not previously been reported in South-East Asia. Here, we report three clinical cases of LRVRE from a teaching hospital in Malaysia. Three isolates of Enterococcus faecium were isolated from three different patients. These isolates were determined to be resistant to both vancomycin and linezolid by Etest gradient diffusion test and Vitek2 automated antibiotic susceptibility testing, respectively. Retrospective analysis of the microbiological and clinical data of the three patients was undertaken. LRVRE were isolated from from tissue and peritoneal fluid of two patients who underwent complicated abdominal surgery. Another patient with underlying acute lymphoblastic leukaemia developed neutropenia following chemotherapy. LRVRE were isolated from the blood culture. All three patients were not treated with linezolid. The possible risk factors for LRVRE acquisition are administration of multiple broad-spectrum antimicrobials and disruption of the gastrointestinal mucosa. The appearance of LRVRE in increasingly widespread geographic locations may lead to a global health threat. Judicious use of broad-spectrum antimicrobials and infection-control practices are crucial to curb its spread.
format	article
author	Wei Chuan Chua Abdul Rahman Zaidah
author_facet	Wei Chuan Chua Abdul Rahman Zaidah
author_sort	Wei Chuan Chua
title	First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
title_short	First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
title_full	First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
title_fullStr	First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
title_full_unstemmed	First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review
title_sort	first reported cases of linezolid-resistant vancomycin-resistant enterococci in south-east asia: a report of three cases and literature review
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/16b62e4e6de04ed6ab0339330334f27c
work_keys_str_mv	AT weichuanchua firstreportedcasesoflinezolidresistantvancomycinresistantenterococciinsoutheastasiaareportofthreecasesandliteraturereview AT abdulrahmanzaidah firstreportedcasesoflinezolidresistantvancomycinresistantenterococciinsoutheastasiaareportofthreecasesandliteraturereview
_version_	1718405887737987072

First reported cases of linezolid-resistant vancomycin-resistant enterococci in South-East Asia: A report of three cases and literature review

Ejemplares similares