The Druze: a population genetic refugium of the Near East.

<h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>...

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Autores principales:	Liran I Shlush, Doron M Behar, Guennady Yudkovsky, Alan Templeton, Yarin Hadid, Fuad Basis, Michael Hammer, Shalev Itzkovitz, Karl Skorecki
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/16b72844ef9f4f4498c7d369efbefd17
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spelling	oai:doaj.org-article:16b72844ef9f4f4498c7d369efbefd172021-11-25T06:12:37ZThe Druze: a population genetic refugium of the Near East.1932-620310.1371/journal.pone.0002105https://doaj.org/article/16b72844ef9f4f4498c7d369efbefd172008-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18461126/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>We have examined mitochondrial DNA sequence variation together with Y-chromosome-based haplogroup structure among the Druze, a religious minority with a unique socio-demographic history residing in the Near East. We observed a striking overall pattern of heterogeneous parental origins, consistent with Druze oral tradition, together with both a high frequency and a high diversity of the mitochondrial DNA (mtDNA) X haplogroup within a confined regional subpopulation. Furthermore demographic modeling indicated low migration rates with nearby populations.<h4>Conclusions</h4>These findings were enabled through the use of a paternal kindred based sampling approach, and suggest that the Galilee Druze represent a population isolate, and that the combination of a high frequency and diversity of the mtDNA X haplogroup signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age.Liran I ShlushDoron M BeharGuennady YudkovskyAlan TempletonYarin HadidFuad BasisMichael HammerShalev ItzkovitzKarl SkoreckiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 5, p e2105 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki The Druze: a population genetic refugium of the Near East.
description	<h4>Background</h4>Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization.<h4>Principal findings</h4>We have examined mitochondrial DNA sequence variation together with Y-chromosome-based haplogroup structure among the Druze, a religious minority with a unique socio-demographic history residing in the Near East. We observed a striking overall pattern of heterogeneous parental origins, consistent with Druze oral tradition, together with both a high frequency and a high diversity of the mitochondrial DNA (mtDNA) X haplogroup within a confined regional subpopulation. Furthermore demographic modeling indicated low migration rates with nearby populations.<h4>Conclusions</h4>These findings were enabled through the use of a paternal kindred based sampling approach, and suggest that the Galilee Druze represent a population isolate, and that the combination of a high frequency and diversity of the mtDNA X haplogroup signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age.
format	article
author	Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki
author_facet	Liran I Shlush Doron M Behar Guennady Yudkovsky Alan Templeton Yarin Hadid Fuad Basis Michael Hammer Shalev Itzkovitz Karl Skorecki
author_sort	Liran I Shlush
title	The Druze: a population genetic refugium of the Near East.
title_short	The Druze: a population genetic refugium of the Near East.
title_full	The Druze: a population genetic refugium of the Near East.
title_fullStr	The Druze: a population genetic refugium of the Near East.
title_full_unstemmed	The Druze: a population genetic refugium of the Near East.
title_sort	druze: a population genetic refugium of the near east.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/16b72844ef9f4f4498c7d369efbefd17
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The Druze: a population genetic refugium of the Near East.

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