Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis

ABSTRACT The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. Once considered an esoteric tropical disease confined to Southeast Asia and northern Australia, research on B. pseudomallei has recently gained gl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tannistha Nandi, Patrick Tan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/16b762467d534ab189fab85f377b52ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:16b762467d534ab189fab85f377b52ec
record_format	dspace
spelling	oai:doaj.org-article:16b762467d534ab189fab85f377b52ec2021-11-15T15:42:48ZLess Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis10.1128/mBio.00709-132150-7511https://doaj.org/article/16b762467d534ab189fab85f377b52ec2013-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00709-13https://doaj.org/toc/2150-7511ABSTRACT The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. Once considered an esoteric tropical disease confined to Southeast Asia and northern Australia, research on B. pseudomallei has recently gained global prominence due to its classification as a potential bioterrorism agent by countries such as the United States and also by increasing numbers of case reports from regions where it is not endemic. An environmental bacterium typically found in soil and water, assessing the true global prevalence of melioidosis is challenged by the fact that clinical symptoms associated with B. pseudomallei infection are extremely varied and may be confused with diverse conditions such as lung cancer, tuberculosis, or Staphyloccocus aureus infection. These diagnostic challenges, coupled with lack of awareness among clinicians, have likely contributed to underdiagnosis and the high mortality rate of melioidosis, as initial treatment is often either inappropriate or delayed. Even after antibiotic treatment, relapses are frequent, and after resolution of acute symptoms, chronic melioidosis can also occur, and the symptoms can persist for months to years. In a recent article, Price et al. [mBio 4(4):e00388-13, 2013, doi:10.1128/mBio.00388-13] demonstrate how comparative genomic sequencing can reveal the repertoire of genetic changes incurred by B. pseudomallei during chronic human infection. Their results have significant clinical ramifications and highlight B. pseudomallei’s ability to survive in a wide range of potential niches within hosts, through the acquisition of genetic adaptations that optimize fitness and resource utilization.Tannistha NandiPatrick TanAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 5 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Tannistha Nandi Patrick Tan Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
description	ABSTRACT The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. Once considered an esoteric tropical disease confined to Southeast Asia and northern Australia, research on B. pseudomallei has recently gained global prominence due to its classification as a potential bioterrorism agent by countries such as the United States and also by increasing numbers of case reports from regions where it is not endemic. An environmental bacterium typically found in soil and water, assessing the true global prevalence of melioidosis is challenged by the fact that clinical symptoms associated with B. pseudomallei infection are extremely varied and may be confused with diverse conditions such as lung cancer, tuberculosis, or Staphyloccocus aureus infection. These diagnostic challenges, coupled with lack of awareness among clinicians, have likely contributed to underdiagnosis and the high mortality rate of melioidosis, as initial treatment is often either inappropriate or delayed. Even after antibiotic treatment, relapses are frequent, and after resolution of acute symptoms, chronic melioidosis can also occur, and the symptoms can persist for months to years. In a recent article, Price et al. [mBio 4(4):e00388-13, 2013, doi:10.1128/mBio.00388-13] demonstrate how comparative genomic sequencing can reveal the repertoire of genetic changes incurred by B. pseudomallei during chronic human infection. Their results have significant clinical ramifications and highlight B. pseudomallei’s ability to survive in a wide range of potential niches within hosts, through the acquisition of genetic adaptations that optimize fitness and resource utilization.
format	article
author	Tannistha Nandi Patrick Tan
author_facet	Tannistha Nandi Patrick Tan
author_sort	Tannistha Nandi
title	Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
title_short	Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
title_full	Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
title_fullStr	Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
title_full_unstemmed	Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis
title_sort	less is more: <named-content content-type="genus-species">burkholderia pseudomallei</named-content> and chronic melioidosis
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/16b762467d534ab189fab85f377b52ec
work_keys_str_mv	AT tannisthanandi lessismorenamedcontentcontenttypegenusspeciesburkholderiapseudomalleinamedcontentandchronicmelioidosis AT patricktan lessismorenamedcontentcontenttypegenusspeciesburkholderiapseudomalleinamedcontentandchronicmelioidosis
_version_	1718427567919202304

Less Is More: <named-content content-type="genus-species">Burkholderia pseudomallei</named-content> and Chronic Melioidosis

Ejemplares similares